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Proliferative Activity and Subpopulation Pattern of Cells in Murine Thymus and Spleen on the Model of Graft-Versus-Host Chronic Reaction under Various Diurnal Regimens of IL-2 Administration

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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the effects of IL-2 administration at different times of day to female B6D2F1 mice with experimental immunopathology, graft-versus-host chronic reaction induced by the administration of lymphoid cells from parental female DBA/2 mice. Recombinant murine IL-2 was injected subcutaneously at 10.00 (group 1) or 16.00 (group 2) after the first cell transfer. Evening administration of IL-2 in contrast to its morning injection prevented cell proliferation in the thymus and spleen, decreased the number of apoptotic splenocytes, significantly stimulated differentiation processes in the thymus, increased the amount of CD4+25high thymocytes, and decreased the number of CD4+27low splenocytes. These findings can serve as a prerequisite for the development of chronotherapeutic schemes for immunocorrection.

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References

  1. R. M. Zaslavskaya, and E. U. Tulemisov, Klin. Med., 86, No. 10, 17–23 (2008).

    Google Scholar 

  2. I. G. Kovshik, A. N. Silkov, S. V. Sennikov, et al., Bull. Exp. Biol. Med., 142, No. 1, 98–101 (2006).

    Article  PubMed  CAS  Google Scholar 

  3. O. T. Kudaeva and O. P. Kolesnikova, Cytokine System. Theoretical and Clinical Aspects. [in Russian], Novosibirsk (2004), pp. 255–268.

  4. G. I. Litvinenko, A. V. Shurlygina, T. I. Dergacheva, et al., Ros. Vestn. Akush. Ginekol., No. 6, 12–15 (2004).

  5. V. A. Trufakin and M. V. Robinson, Morfo-cytochemical Methods for the Estimation of Immunocompetent Cells and Immune Organs: Methodical Recommendations [in Russian], Novosibirsk (1990).

  6. A. V. Shurlygina, I. G. Kovshik, L. V. Verbitskaya, and V. A. Trufakin, Immunologiya, No. 1, 21–24 (2000).

  7. A. V. Shurlygina, T. I. Dergacheva, V. S. Dergachev et al., Patent USSR No. 1780752, The Method of Immunotherapy (1993).

  8. T. Bollinger, A. Bollinger, J. Naujoks, et al., Immunology, 131, No. 4, 488–500 (2010).

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  9. V. Kalia, S. Sarkar, S. Subramaniam, et al., Immunity, 32, No. 1, 91–103 (2010).

    Article  PubMed  CAS  Google Scholar 

  10. M. A. Kapina, G. S. Shepelkova, V. V. Mischenko, et al., J. Immunol., 178, No. 2, 976–985 (2007).

    PubMed  CAS  Google Scholar 

  11. I. G. Kovshik, A. V. Shurlygina, S. V. Sennikov, et al., Bull. Exp. Biol. Med., 144, No. 4, 566–569 (2007).

    Article  PubMed  CAS  Google Scholar 

  12. H. Kuriyama, S. Watanabe, J. Kjaergaard, et al., Cell. Immunol., 243, No. 1, 30–40 (2006).

    Article  PubMed  CAS  Google Scholar 

  13. G. Mazzoccoli, R. B. Sothern, A. De Cata, et al., J. Biol. Regul. Homeost. Agents, 25, No. 3, 387–395 (2011).

    PubMed  CAS  Google Scholar 

  14. A. Schiött, M. Lindstedt, B. Johansson-Lindbom, et al., Immunology, 113, No. 3, 363–370 (2004).

    Article  PubMed  PubMed Central  Google Scholar 

  15. M. H. Smolensky, B. Lemmer, and A. E. Reinberg, Adv. Drug Deliv. Rev., 59, Nos. 9-10, 852–882 (2007).

    Article  PubMed  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Research Institute of Clinical and Experimental Lymphology, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk, Russia

    A. V. Shurlygina, I. G. Kovshik, E. V. Mel’nikova & N. G. Panteleeva

  2. Research Institute of Clinical Immunology, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk, Russia

    O. T. Kudaeva, O. P. Kolesnikova & E. V. Gojman

  3. Research Institute of Physiology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia

    V. A. Trufakin

Authors
  1. A. V. Shurlygina
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  2. O. T. Kudaeva
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  3. O. P. Kolesnikova
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  4. E. V. Gojman
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  5. I. G. Kovshik
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  6. E. V. Mel’nikova
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  7. N. G. Panteleeva
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  8. V. A. Trufakin
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Corresponding author

Correspondence to A. V. Shurlygina.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 156, No. 7, pp. 85-89, July, 2013

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Shurlygina, A.V., Kudaeva, O.T., Kolesnikova, O.P. et al. Proliferative Activity and Subpopulation Pattern of Cells in Murine Thymus and Spleen on the Model of Graft-Versus-Host Chronic Reaction under Various Diurnal Regimens of IL-2 Administration. Bull Exp Biol Med 156, 73–77 (2013). https://doi.org/10.1007/s10517-013-2281-3

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  • DOI: https://doi.org/10.1007/s10517-013-2281-3

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