Daily (for 3 days) 1-hour immobilizations were followed by an increase in protein oxidative modification and leukocyte infiltration in the liver, and a decrease in monoamine oxidase B activity. Receptor antagonist of glucocorticoids RU38486 limited the stress-induced increase in protein carbonylation and decrease in monoamine oxidase B activity in the organ and enhanced leukocyte infiltration of the liver.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 156, No. 7, pp. 38-40, July, 2013
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Tseilikman, V.E., Ryabinin, V.E., Tseilikman, O.B. et al. Effects of Glucocorticoid Antagonist on Protein Carbonylation in Rat Liver after Daily 1-hour Immobilizations. Bull Exp Biol Med 156, 29–31 (2013). https://doi.org/10.1007/s10517-013-2269-z
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DOI: https://doi.org/10.1007/s10517-013-2269-z