The authors present a method for experimental reproduction of stages of the acute respiratory distress syndrome development, including the initial stage -acute pulmonary injury. Concentrated neutrophil transmitters served as the factor triggering the development of the process. The adequacy of the model was confirmed by the clear-cut morphological stages of the process. The possibility of reproducing the syndrome by injection of concentrated neutrophil transmitters confirmed their leading role in impairment of the alveolar capillary membrane.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 155, No. 6, pp. 784-787, June, 2013
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Prutkina, E.V., Sepp, A.V., Tsybikov, N.N. et al. Experimental Reproduction of Stages of the Respiratory Distress Syndrome. Bull Exp Biol Med 155, 817–820 (2013). https://doi.org/10.1007/s10517-013-2260-8
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DOI: https://doi.org/10.1007/s10517-013-2260-8