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Effects on Alimentary High-Fat Diet on Thiol Disulfide Homeostasis in Rats

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Bulletin of Experimental Biology and Medicine Aims and scope

The effects of high-fat diet on the thiol disulfide homeostasis of rats were evaluated by activities of glutathione redox system functioning in the blood and liver. A short-term (30 days) high-fat diet inhibited activities of glutathione-dependent enzymes. High-fat loading for 90 days promoted the development of a compensatory response of the glutathione redox system and restoration of the thiol disulfide homeostasis. The compensatory processes in the glutathione system failed on day 180 of alimentary loading because of redox imbalance in the thiol disulfide metabolism.

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References

  1. V. A. Dotsenko, Vopr. Pitan., No. 6, 36–39 (2004).

  2. Yu. K. Karaman, T. P. Novgorodtseva, and N. V. Zhukova, Bull. Exp. Biol. Med., 150, No. 3, 291–294 (2010).

    Article  Google Scholar 

  3. Yu. K. Karaman, T. P. Novgorodtseva, T. I. Vitkina, et al., Patol. Fiziol. Eksp. Ter., No. 2, 44–46 (2011).

  4. V. I. Kulinsky and L. S. Kolesnichenko, Biomed. Khim., 55, No. 3, 255–277 (2009).

    Google Scholar 

  5. V. I. Kulinsky and L. S. Kolesnichenko, Biomed. Khim., 55, No. 4, 365–379 (2009).

    Google Scholar 

  6. T. P. Novgorodtseva, E. E. Endakova, and V. I. Yan’kova, Manual of Methods for Studies of the Lipid Peroxidation-Antioxidant Defense Parameters in Biological Fluids [in Russian], Vladivostok (2003).

  7. E. A. Stepovaya, T. V. Zhavoronok, G. V. Petina, et al., Byull. Sib. Otdel. Rossiisk. Akad. Med. Nauk, 3, No. 5, 64–69 (2010).

    Google Scholar 

  8. V. A. Tutelyan, V. B. Spirichev, B. P. Sukhanov, et al., Micronutrients in Rations for Normal Subjects and Patients: Hand book of Vitamins and Minerals. Manual for Continuous Me dical Education [in Russian], Moscow (2002).

  9. J. G. Fan, L. Zhong, and Z. J. Xu, World J. Gastroenterol., 9, No. 9, 2045–2049 (2003).

    PubMed  Google Scholar 

  10. R. Kinscherf, K. Cafaltzis, and F. Roder, Free Radic. Biol. Med., 35, No. 10, 1286–1292 (2003).

    Article  PubMed  CAS  Google Scholar 

  11. H. Nagai, K. Matsumaru, G. Feng, and N. Kaplowitz, Hepatology, 36, No. 1, 5–64 (2002).

    Article  Google Scholar 

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Authors and Affiliations

  1. Research Institute of Medical Climatology and Rehabilitative Treatment, Vladivostok Affiliated Department of Far-Eastern Center of Respiratory Physiology and Pathology, Siberian Division of the Russian Academy of Medical Sciences, Moscow, Russia

    Yu. K. Karaman, T. P. Novgorodtseva & V. I. Yan’kova

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  1. Yu. K. Karaman
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  2. T. P. Novgorodtseva
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  3. V. I. Yan’kova
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Correspondence to Yu. K. Karaman.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 155, No. 6, pp. 714-718, June, 2013

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Karaman, Y.K., Novgorodtseva, T.P. & Yan’kova, V.I. Effects on Alimentary High-Fat Diet on Thiol Disulfide Homeostasis in Rats. Bull Exp Biol Med 155, 752–756 (2013). https://doi.org/10.1007/s10517-013-2244-8

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  • DOI: https://doi.org/10.1007/s10517-013-2244-8

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