We studied the effect of gold nanospheres coated with components of autologous blood plasma on ADP-induced platelet aggregation. Gold nanoparticles in the chosen concentration range (5–40 μM) and particle size (5–30 nm) with or without coating produced no activating effect on platelet aggregation caused by aggregation inductor ADP in all applied doses (1.6, 2.0, and 5.0 μM). Nanoparticles with a diameter of >60 nm inhibited platelet aggregation. These findings and published data confirm the biological safety of gold nanoparticles for targeted delivery of drugs and phototherapy.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 155, No. 5, pp. 639–643, May, 2013
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Aseychev, A.V., Azizova, O.A., Beckman, E.M. et al. Effect of Gold Nanoparticles Coated with Plasma Components on ADP-Induced Platelet Aggregation. Bull Exp Biol Med 155, 685–688 (2013). https://doi.org/10.1007/s10517-013-2226-x
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DOI: https://doi.org/10.1007/s10517-013-2226-x