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Phenotypic Differences between mdx Black Mice and mdx Albino Mice. Comparison of Cytokine Levels in the Blood

Bulletin of Experimental Biology and Medicine volume 155, pages 376–379 (2013)Cite this article

In mdx mice, mutation in the muscle protein dystrophin gene results in the development of chronic degeneration of the muscle tissue. We performed a comparative analysis of blood cytokine levels in mdx mice, classical black mice and mice with additional genetic defect responsible for the manifestations of oculocutaneous albinism. In mdx albino mice, the total pool of cytokines (IL-10, IL-6, IL-5, IL-2, IL-1α, IL-4, IL-17, granulocyte-macrophage growth factor, TNF-α, and IFN-γ) was increased. This increase was not associated with selective release of one of the above cytokines into the blood. The fraction of pro-inflammatory cytokines (IL-6, IL-1α, TNF-α) was increased in the total pool and the percentage of antiinflammatory cytokines (IL-4) was reduced. Changes in cytokine pool probably reflect the differences in the severity of the pathological process in the muscle tissue of both genetic variations of mdx mice.

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Affiliations

  1. N. I. Pirogov Russian National Research Medical University, Moscow, Russia

    M. A. Stenina, L. I. Krivov, D. A. Voevodin & V. N. Yarygin

Authors
  1. M. A. Stenina
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  2. L. I. Krivov
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  3. D. A. Voevodin
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  4. V. N. Yarygin
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Corresponding author

Correspondence to M. A. Stenina.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 155, No. 3, pp. 355-358, March, 2013

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Stenina, M.A., Krivov, L.I., Voevodin, D.A. et al. Phenotypic Differences between mdx Black Mice and mdx Albino Mice. Comparison of Cytokine Levels in the Blood. Bull Exp Biol Med 155, 376–379 (2013). https://doi.org/10.1007/s10517-013-2158-5

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  • DOI: https://doi.org/10.1007/s10517-013-2158-5

Key Words

  • mdx mice
  • cytokines
  • c-albino locus