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Mechanisms of Hemostimulating Effect of Aconitum baicalense Diterpene Alkaloids

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Bulletin of Experimental Biology and Medicine Aims and scope

A mixture of diterpene alkaloids of Aconitum baicalense exhibited pronounced regenerative hemostimulating properties on the model of cytostatic myelosuppression. The therapeutic effect is based on activation of hemopoietic progenitor cells against the background of increased feeder capacity of stromal compartment of the hemopoiesis-inducing microenvironment and decreased count of mesenchymal stem cells in the bone marrow.

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Authors and Affiliations

  1. Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia

    G. N. Zyuz’kov, V. V. Zhdanov, L. A. Miroshnichenko, E. V. Udut, E. V. Simanina, L. A. Stavrova, V. I. Agafonov, A. V. Chaikovskiy, M. Yu. Minakova, T. N. Povet’eva, N. I. Suslov, A. V. Krapivin, Yu. V. Nesterova, D. V. Reykhart & A. M. Dygai

  2. National Research Irkutsk State Technical University, Irkutsk, Russia

    A. A. Semenov

Authors
  1. G. N. Zyuz’kov
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  2. V. V. Zhdanov
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  3. L. A. Miroshnichenko
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  4. E. V. Udut
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  5. E. V. Simanina
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  6. L. A. Stavrova
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  7. V. I. Agafonov
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  8. A. V. Chaikovskiy
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  9. M. Yu. Minakova
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  10. T. N. Povet’eva
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  11. N. I. Suslov
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  12. A. V. Krapivin
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  13. Yu. V. Nesterova
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  14. A. A. Semenov
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  15. D. V. Reykhart
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  16. A. M. Dygai
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Corresponding author

Correspondence to G. N. Zyuz’kov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 155, No. 3, pp. 327–330, March, 2013

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Zyuz’kov, G.N., Zhdanov, V.V., Miroshnichenko, L.A. et al. Mechanisms of Hemostimulating Effect of Aconitum baicalense Diterpene Alkaloids. Bull Exp Biol Med 155, 350–353 (2013). https://doi.org/10.1007/s10517-013-2151-z

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  • DOI: https://doi.org/10.1007/s10517-013-2151-z

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