Neuroprotective Effects of Dipeptide Analogue of Brain-Derived Neurotrophic Factor GSB-106 in In Vitro Experiments

Dimeric dipeptide GSB-106, a novel structural analogue of neurotrophin BDNF, in doses from 10−5 to 10−8 M protected cultured immortalized mouse hippocampal HT-22 neurons from H2O2 or glutamate damage. The neuroprotective effect of GSB-106 was also shown on cultured SH-SY5Y human neuroblastoma cells after treatment with neurotoxin 6-hydroxidopamine. These data attest to functional similarity of GSB-106 and neurotrophin BDNF.

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Correspondence to I. O. Logvinov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 155, No. 3, pp. 319-322, March, 2013

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Logvinov, I.O., Antipova, T.A., Gudasheva, T.A. et al. Neuroprotective Effects of Dipeptide Analogue of Brain-Derived Neurotrophic Factor GSB-106 in In Vitro Experiments. Bull Exp Biol Med 155, 343–345 (2013). https://doi.org/10.1007/s10517-013-2149-6

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Key Words

  • neuroprotection
  • BDNF
  • GSB-106
  • dipeptide mimetic of BDNF