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Vasomotor Activity of the Aorta during Chronic Smoking Modeling

  • General Pathology and Pathophysiology
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Bulletin of Experimental Biology and Medicine Aims and scope

We studied vasomotor responses of aortic endothelium in a rat model of chronic smoking. It was found that long-term exposure to tobacco smoke (inhalation) impaired vasomotor function of the aortic endothelium leading to insufficient vasodilator activity and enhanced vasoconstriction. After the cessation of inhalations, vasomotor disturbances were not only preserved, but also exacerbated because of increased pathological endothelium-independent vasoconstriction.

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Authors and Affiliations

  1. Vladivostok State Medical University, Vladivostok, Russia

    N. V. Zakharchuk, V. A. Nevzorova & E. Y. Gonchar

  2. Pacific Institute of Bioorganic Chemistry Far East Division of Russian Academy of Sciences, Vladivostok, Russia

    I. G. Agafonova

Authors
  1. N. V. Zakharchuk
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  2. V. A. Nevzorova
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  3. E. Y. Gonchar
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  4. I. G. Agafonova
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Corresponding author

Correspondence to N. V. Zakharchuk.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 155, No. 3, pp. 275-278, March, 2013

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Zakharchuk, N.V., Nevzorova, V.A., Gonchar, E.Y. et al. Vasomotor Activity of the Aorta during Chronic Smoking Modeling. Bull Exp Biol Med 155, 302–305 (2013). https://doi.org/10.1007/s10517-013-2138-9

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  • DOI: https://doi.org/10.1007/s10517-013-2138-9

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