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Pathomorphological Analysis of the Pancreaticoduodenal Organs in Experimental Pancreonecrosis Induced by Trypsin Injection

  • Morphology and Pathomorphology
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Bulletin of Experimental Biology and Medicine Aims and scope

Acute experimental pancreatitis induced by injection of trypsin into the pancreatic tissue exhibited characteristics of fulminant hemorrhagic pancreonecrosis (intense exudation of interlobular stroma, massive plasmo- and hemorrhages, foci of acinar cell autolysis involving by the end of day 1 an appreciable portion of the organ with formation of fields of necrosis and hemorrhagic imbibition of the glandular parenchyma, virtually completely without demarcation cellular reaction). Marked microcirculatory disorders and degenerative and necrobiotic changes in the duodenal mucosa and liver reflected the polyorgan nature of the pathological process. This model of hemorrhagic pancreonecrosis corresponded to the most severe forms of this conditions observed clinically.

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Authors and Affiliations

  1. Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia

    L. M. Nepomnyashchikh, M. A. Bakarev, A. V. Vasilyev & S. I. Protsenko

Authors
  1. L. M. Nepomnyashchikh
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  2. M. A. Bakarev
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  3. A. V. Vasilyev
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  4. S. I. Protsenko
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Corresponding author

Correspondence to L. M. Nepomnyashchikh.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 155, No. 2, pp. 218-223, February, 2013

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Nepomnyashchikh, L.M., Bakarev, M.A., Vasilyev, A.V. et al. Pathomorphological Analysis of the Pancreaticoduodenal Organs in Experimental Pancreonecrosis Induced by Trypsin Injection. Bull Exp Biol Med 155, 249–254 (2013). https://doi.org/10.1007/s10517-013-2125-1

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  • DOI: https://doi.org/10.1007/s10517-013-2125-1

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