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Use of Inclusion Complex of Cyclodextrin with Ambenonium to Improve the Treatment of Anticholinesterase Poisoning

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Bulletin of Experimental Biology and Medicine Aims and scope

The complex of ambenonium with methyl-β-cyclodextrin injected intramuscularly to rats caused more pronounced inhibition of acetylcholinesterase in erythrocyte and brain than free drug. The use of this complex as part of combined therapy significantly reduces mortality in animals during experimental anticholinesterase poisoning in comparison with the controls.

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Authors and Affiliations

  1. Research and Testing Institute of Military Medicine, S. M. Kirov Military Medical Academy, St. Petersburg, Russia

    M. A. Yudin, I. M. Ivanov, A. S. Nikiforov, T. M. Kornyukhina & M. A. Tyunin

Authors
  1. M. A. Yudin
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  2. I. M. Ivanov
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  3. A. S. Nikiforov
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  4. T. M. Kornyukhina
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  5. M. A. Tyunin
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Correspondence to M. A. Yudin.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 155, No. 2, pp. 185-187, February, 2013

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Yudin, M.A., Ivanov, I.M., Nikiforov, A.S. et al. Use of Inclusion Complex of Cyclodextrin with Ambenonium to Improve the Treatment of Anticholinesterase Poisoning. Bull Exp Biol Med 155, 218–220 (2013). https://doi.org/10.1007/s10517-013-2117-1

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  • DOI: https://doi.org/10.1007/s10517-013-2117-1

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