We studied the effects of injections of 5-HT1A-agonist buspirone to pregnant rats before stress exposure on corticosterone level in the dynamics of stress response to inflammatory-induced pain in 7-day-old offspring. During the period of the hypothalamic–pituitary–adrenal system hyporeactivity, the pain response in the formalin test was associated with stress-related corticosterone variations. Maternal buspirone normalized the pain reaction in prenatally stressed rats during all periods of the formalin test and modified the dynamics of the corticosterone response. In 1 day after the formalin test, the basal level of this hormone in blood plasma remained increased. Maternal buspirone increased the resistance of the nociceptive and stresssystems to inflammatory-induced pain response in prenatally stressed rats.
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References
I. P. Butkevich, V. A. Mikhailenko, E. A. Vershinina, et al., Zh. Evoluts. Fiziol. Biokhim., 45, No. 5, 492–497 (2009).
I. P. Butkevich, V. A. Mikhailenko, E. A. Vershinina, et al., Brain Res., 1419, 76–84 (2011).
M. F. Dallman, Endocrinology, 141, No. 5, 1590–1592 (2000).
L. P. Filaretova, A. A. Filaretov, and G. B. Makara, Am. J. Physiol., 247, No. 6, Pt. 1, G1024–1030 (1998).
J. A. Markham and J. I. Koenig, Psychopharmacology (Berl), 214, No. 1, 89–106 (2011).
M. J. Millan, Pain, 58, No. 1, 45–61 (1994).
G. Pavlakovic, J. Tigges, and T.A. Crozier, BMC Clin. Pharmacol., 9, 12 (2009).
H. M. van Praag, Prog. Neuropsychopharmacol. Biol. Psychiatry, 28, No. 5, 891–907 (2004).
J. Savitz, I. Lucki, and W. C. Drevets, Prog. Neurobiol., 88, No. 1, 17–31 (2009).
J. R. Seckl, Prog. Brain Res., 167, 17–34 (2008).
M. Weinstock, Isr. J. Psychiatry Relat. Sci., 47, No. 1, 36–45 (2010).
C. S. Wyrwoll and M. C. Holmes, Neuroendocrinology, 2011, Oct. 25. PMID: 22042385.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 155, No. 2, pp. 156-159, February, 2013
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Butkevich, I.P., Mikhailenko, V.A., Makukhina, G.V. et al. Tonic Pain Response during Inflammation and Stress-Induced Corticosterone Variations in Prenatally Stressed Infant Rats: Effects of Maternal Buspirone Injected during Pregnancy. Bull Exp Biol Med 155, 194–196 (2013). https://doi.org/10.1007/s10517-013-2110-8
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DOI: https://doi.org/10.1007/s10517-013-2110-8