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Effect of Prolyl Endopeptidase Inhibitor Benzyloxycarbonyl-Methionyl-2(S)-Cyanopyrrolidine on the Course of Experimental Depressive Syndrome in Rats

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The effects of noncompetitive prolyl endopeptidase inhibitor benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine were studied in rats with the experimental dopamine deficiency-dependent depressive syndrome induced by systemic injections of a pre-neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridin for 14 days. The inhibitor (3.0 mg/kg, i.p., 30 min before pre-neurotoxin injection on days 8-14) alleviated depression symptoms and promoted normalization of behavioral activity after drug withdrawal. The obtained data reflected therapeutic antidepressant properties of inhibitor for prolyl endopeptidase benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine.

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References

  1. N. A. Krupina, N. G. Bogdanova, N. N. Khlebnikova, et al., Bull. Exp. Biol. Med., 154, No. 5, 606–609 (2013).

    Article  PubMed  CAS  Google Scholar 

  2. N. A. Krupina, N. N. Zolotov, N. G. Bogdanova, et al., Ibid., 142, No. 5, 554–556 (2006).

    Article  PubMed  CAS  Google Scholar 

  3. N. A. Krupina, E. Yu. Kushnareva, N. N. Khlebnikova, et al., Zh. Vyssh. Nervn. Deiat., 59, No. 3, 360–372 (2009).

    CAS  Google Scholar 

  4. N. A. Krupina, I. N. Orlova, and G. N. Kryzhanovskii, Bull. Exp. Biol. Med., 120, No. 2, 805–808 (1995).

    Article  Google Scholar 

  5. N. A. Krupina, I. N. Orlova, and G. N. Kryzhanovskii, Zh. Vyssh. Nervn. Deiat., 49, No. 5, 864–875 (1999).

    CAS  Google Scholar 

  6. G. N. Kryzhanovskii, N. A. Krupina, and V. G. Kucherianu, Ibid., 45, No. 2, 377–387 (1995).

    CAS  Google Scholar 

  7. E. Yu. Kushnareva, N. A. Krupina, N. N. Khlebnikova, et al., Bull. Exp. Biol. Med., 151, No. 6, 675–679 (2011).

    Article  PubMed  CAS  Google Scholar 

  8. N. N. Khlebnikova, N. A. Krupina, N. G. Bogdanova, et al., Ibid., 147, No. 1, 26–30 (2009).

    Article  PubMed  CAS  Google Scholar 

  9. N. N. Khlebnikova, N. A. Krupina, E. Yu. Kushnareva, et al., Ibid., 152, No. 4, 409–412 (2012).

    Article  PubMed  CAS  Google Scholar 

  10. N. N. Khlebnikova, N. A. Krupina, I. N. Orlova, et al., Ibid., 147, No. 3, 291–295 (2009).

    Article  PubMed  CAS  Google Scholar 

  11. J. A. García-Horsman, P. T. Männistö, and J. I. Venäläinen, Neuropeptides, 41, No. 1, 1–24 (2007).

    Article  PubMed  Google Scholar 

  12. J. Guidi, G. A. Fava, P. Bech, and E. Paykel, Psychother. Psychosom., 80, No. 1, 10–27 (2011).

    Article  PubMed  Google Scholar 

  13. T. Karl, T. Hoffmann, R. Pabst, and S. von Hörsten, Physiol. Behav., 80, No. 1, 123–134 (2003).

    Article  PubMed  CAS  Google Scholar 

  14. M. Maes and S. Bonaccorso, Acta Psychiatr. Scand., 109, No. 2, 126–131 (2004).

    Article  PubMed  CAS  Google Scholar 

  15. P. Morain, P. H. Boeijinga, A. Demazières, et al., Neuropsychobiology, 55, Nos. 3-4, 176–183 (2007).

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Laboratory of General Pathology of the Nervous System, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia

    N. N. Khlebnikova, N. A. Krupina, N. G. Bogdanova & I. N. Orlova

  2. Laboratory for Psychopharmacology, V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia

    N. N. Zoloto

Authors
  1. N. N. Khlebnikova
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  2. N. A. Krupina
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  3. N. G. Bogdanova
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  4. I. N. Orlova
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  5. N. N. Zoloto
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Correspondence to N. N. Khlebnikova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 155, No. 2, pp. 151-155, February, 2013

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Khlebnikova, N.N., Krupina, N.A., Bogdanova, N.G. et al. Effect of Prolyl Endopeptidase Inhibitor Benzyloxycarbonyl-Methionyl-2(S)-Cyanopyrrolidine on the Course of Experimental Depressive Syndrome in Rats. Bull Exp Biol Med 155, 190–193 (2013). https://doi.org/10.1007/s10517-013-2109-1

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  • DOI: https://doi.org/10.1007/s10517-013-2109-1

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