We studied multipotent mesenchymal stromal cells isolated from the bone marrow of young (1 month) and old (>12 months) rats. The cell cultures derived from old rats were characterized by lower cell yield in the primary culture, lower number of doublings, and reduced colony-forming capacity of precursor cells.
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Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 1, pp. 11-15, January, 2013
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Valyushina, M.P., Buravkova, L.B. Age-Related Differences in Rat Multipotent Mesenchymal Stromal Bone Marrow Cells. Bull Exp Biol Med 155, 129–133 (2013). https://doi.org/10.1007/s10517-013-2097-1
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DOI: https://doi.org/10.1007/s10517-013-2097-1