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Activity of Succinate Dehydrogenase in the Neocortex and Hippocampus of Mongolian Gerbils with Ischemic and Reperfusion Brain Injury

Bulletin of Experimental Biology and Medicine volume 155, pages 14–17 (2013)Cite this article

We analyzed changes in activity of SDH, one of the most important enzymes of the Krebs cycle, in the cytoplasm of hippocampal and cortical neurons of Mongolian gerbils (Meriones unguiculatus) at the early and delayed reperfusion period after global brain ischemia. The data indicate that SDH activity in pyramidal neurons of various hippocampal areas and in neurons of II, III and V layers of cerebral cortex after 7-min forebrain ischemia depends on both the localization of these neurons and duration of the postischemic reperfusion. SDH activity in neurons significantly increased on days 2 and 7 after reperfusion.

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Affiliations

  1. I. P. Pavlov St. Petersburg State Medical University, St. Petersburg, Russia

    N. S. Shcherbak, M. M. Galagudza, D. A. Ovchinnikov, A. N. Kuzmenkov, G. Yu. Yukina, E. R. Barantsevich, V. V. Tomson & E. V. Shlyakhto

  2. V. A. Almazov Federal Center of the Heart, Blood, and Endocrinology, St. Petersburg, Russia

    N. S. Shcherbak, M. M. Galagudza, D. A. Ovchinnikov, A. N. Kuzmenkov, E. R. Barantsevich & E. V. Shlyakhto

Authors
  1. N. S. Shcherbak
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  2. M. M. Galagudza
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  3. D. A. Ovchinnikov
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  4. A. N. Kuzmenkov
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  5. G. Yu. Yukina
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  6. E. R. Barantsevich
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  7. V. V. Tomson
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  8. E. V. Shlyakhto
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Correspondence to N. S. Shcherbak.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 155, No. 1, pp. 17–20, January, 2013

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Shcherbak, N.S., Galagudza, M.M., Ovchinnikov, D.A. et al. Activity of Succinate Dehydrogenase in the Neocortex and Hippocampus of Mongolian Gerbils with Ischemic and Reperfusion Brain Injury. Bull Exp Biol Med 155, 14–17 (2013). https://doi.org/10.1007/s10517-013-2068-6

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  • DOI: https://doi.org/10.1007/s10517-013-2068-6

Keywords

  • succinate dehydrogenase
  • brain
  • ischemia-reperfusion
  • Mongolian gerbil