Comparative morphological study of the placentas from women with pre-eclampsia of different severity was carried out. The expression of vascular endothelial growth factor and its receptors (VEGFR-1, VEGFR-2, VEGFR-3) was studied by immunohistochemical methods. Branched angiogenesis processes predominated in the placentas of patients with pre-eclampsia. The syncytiocapillary membranes were thickened, the number of syncytial buds was greater than normally. Immunohistochemical studies showed high expression of VEGF and VEGFR-1 and low expression of VEGFR-2 in the placental villous structures.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
T. K. Grebennik and S. V. Pavlovich, Akush. Ginekol., No. 6, 17–21 (2011).
K. A. Pavlov, E. A. Dubova, and A. I. Shchyogolev, Ibid., No. 6, 10–15 (2010).
F. Akercan, T. Cirpan, M. C. Terek, et al., Arch. Gynecol. Obstetr., 277, No. 2, 109–114 (2008).
P. M. Bosio, T. Wheeler, F. Anthony, et al., Am. J. Obstetr. Gynecol., 184, No. 2, 146–152 (2001).
Z. Cheng, Q. Lin, and Z. Shen, Zhonghua Fu Chaan Ke Za Zhi, 36, 72–75 (2001).
L. Driul, G. Damante, A. D’Elia, et al., Minerva. Ginecol., 56, No. 5, 385–390 (2004).
L. Leach, M. O. Babawale, M. Anderson, and M. Lammiaman, J. Vasc. Res., 39, No. 3, 246–259 (2002).
R. J. Levine and S. A. Karumanchi, Clin. Obstet. Gynecol., 48, No. 2, 372–386 (2005).
J. C. Livingston, R. Chin, B. Haddad, et al., Am. J. Obstetr. Gynecol., 183, No. 6, 1554–1557 (2000).
E. Sgambati, M. Marini, G. D. Zappoli Thyrion, et al., BJOG, 111, No. 6, 564–570 (2004).
M. Shibuya, Proc. Jpn. Acad. Ser. B. Phys. Biol. Sci., 87, No. 4, 167–178 (2011).
B. Sibai, G. Dekker, and M. Kupferminc, Lancet, 365, 785–799 (2005).
R. N. Taylor, J. Grimwood, R. S. Taylor, et al., Am. J. Obstetr. Gynecol., 188, No. 1, 177–182 (2003).
D. S. Torry, M. Hinrichs, and R. J. Torry, Am. J. Reprod. Immunol., 51, No. 4, 257–268 (2004).
R. Tripathi, G. Rath, R. Ralhan, et al., Yonsei. Med. J., 50, No. 5, 656–666 (2009).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 154, No. 12, pp. 761-765, December, 2012
Rights and permissions
About this article
Cite this article
Dubova, E.A., Pavlov, K.A., Lyapin, V.M. et al. Vascular Endothelial Growth Factor and Its Receptors in the Placental Villi of Pregnant Patients with Pre-Eclampsia. Bull Exp Biol Med 154, 792–795 (2013). https://doi.org/10.1007/s10517-013-2058-8
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-013-2058-8