The levels of spontaneous and mitogen-induced production of pro- and anti-inflammatory cytokines were studied in patients with chronic lymphoid leukemia, non-Hodgkin’s lymphocytic lymphomas, and multiple myeloma during the course of chemotherapy. Cytokine concentrations varied within a great range and did not conform to the normal distribution law. The levels of granulocyte and granulocyte-macrophage CSF were high during the debut, progress, and remission of the lymphoproliferative diseases. Imbalance of a wide spectrum of pro- and anti-inflammatory cytokines was observed during the debut and progress of the lymphoproliferative diseases, more often in chronic lymphoid leukemia and non-Hodgkin’s lymphocytic lymphomas than in multiple myeloma.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 154, No. 12, pp. 754-757, December, 2012
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Domnikova, N.P., Dolgikh, T.Y., D’yachkova, Y.A. et al. Spontaneous and Mitogen-Induced Cytokine Production in Lymphoproliferative Diseases. Bull Exp Biol Med 154, 785–788 (2013). https://doi.org/10.1007/s10517-013-2056-x
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DOI: https://doi.org/10.1007/s10517-013-2056-x