Plasma γ-globulin fraction proteins, copper and zinc cations, and metal complexes of these cations and human serum γ-globulin induce the production of TNF-α by human blood cells. The protein modified by zinc cations is by 1.4-1.7 times more potent (p<0.001-0.01) than control γ-globulin in inducing the production of TNF-α, while metal complex formed by γ-globulin and copper is by 1.9-2.2 times more potent that the control protein (p<0.001). Under conditions of experimental induction, TNF-α is produced as a typical early response cytokine. During long-term incubation, copper cations lose the ability to induce TNF-α production, while in combination with γ-globulin these cations produce a synergistic effect with the control protein.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 154, No. 12, pp. 726–729, December, 2012
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Cheknev, S.B., Efremova, I.E., Apresova, M.A. et al. Induction of TNF-α Production by Metal Complexes of γ-Globulin Fraction Proteins and Copper and Zinc Cations. Bull Exp Biol Med 154, 758–761 (2013). https://doi.org/10.1007/s10517-013-2049-9
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DOI: https://doi.org/10.1007/s10517-013-2049-9