Pegylated hyaluronate-endo-β-N-acetylhexosaminidase was shown to potentiate significantly the hemostimulatory effect of pegylated erythropoietin. It was found that enhanced production of hemopoietin by adherent and non-adherent cells of the hemopoiesis-inducing microenvironment and elevated serum content of endogenous erythropoietin along with increased susceptibility of erythroid precursors to pegylated erythropoietin underlay this phenomenon.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 154, No. 12, pp. 717–722, December, 2012
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Dygai, A.M., Zyuz’kov, G.N., Zhdanov, V.V. et al. Mechanisms Underlying Modulation of the Pharmacological Properties of Pegylated Erythropoietin by Pegylated Hyaluronate-Endo-β-N-Acetylhexosaminidase. Bull Exp Biol Med 154, 750–754 (2013). https://doi.org/10.1007/s10517-013-2047-y
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DOI: https://doi.org/10.1007/s10517-013-2047-y