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Effect of Ultrasonic Irradiation on the Development of Symptoms of Depression and Anxiety in Rats

  • BIOPHYSICS AND BIOCHEMISTRY
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Bulletin of Experimental Biology and Medicine Aims and scope

Behavioral reactions of rats were studied under conditions of constant exposure to ultrasonic irradiation at a frequency of 20–45 kHz for 21 days. In rats subjected to ultrasound, impaired behavior in the social interest test and Porsolt forced swimming test was observed; the development of anhedonia in the sucrose preference test was revealed (manifested in the symptoms of depression). The effects of ultrasonic irradiation were abolished by an antidepressant fluoxetine, a selective serotonin reuptake inhibitor. Our results indicate that chronic exposure to ultrasonic radiation produces a modulatory effect on depressive symptoms in rats. These changes satisfy the requirements for experimental animals, which are used as a model of psychopathological processes.

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Authors and Affiliations

  1. Department of Basic and Applied Neurobiology, V. P. Serbsky State Research Center for Social and Forensic Psychiatry, Ministry of Health and Social Development of the Russian Federation, Moscow, Russia

    A. Yu. Morozova, E. A. Zubkov, Z. I. Storozheva, Z. I. Kekelidze & V. P. Chekhonin

  2. N. I. Pirogov Russian National Research Medical University, Ministry of Health and Social Development of the Russian Federation, Moscow, Russia

    V. P. Chekhonin

  3. P. K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia

    Z. I. Storozheva

Authors
  1. A. Yu. Morozova
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  2. E. A. Zubkov
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  3. Z. I. Storozheva
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  4. Z. I. Kekelidze
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  5. V. P. Chekhonin
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Corresponding author

Correspondence to A. Yu. Morozova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 154, No. 12, pp. 705–708, December, 2012

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Morozova, A.Y., Zubkov, E.A., Storozheva, Z.I. et al. Effect of Ultrasonic Irradiation on the Development of Symptoms of Depression and Anxiety in Rats. Bull Exp Biol Med 154, 740–743 (2013). https://doi.org/10.1007/s10517-013-2044-1

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  • DOI: https://doi.org/10.1007/s10517-013-2044-1

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