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Morphological Study of Burn Wound Healing with the Use of Collagen-Chitosan Wound Dressing

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Bulletin of Experimental Biology and Medicine Aims and scope

Experiments on the model of thermal skin burn in rats showed that the use of wound dressing based on collagen-chitosan complex Kollakhit-Bol in local treatment of grade IIIb skin burns increased healing rate by accelerating the formation of granulation and fi brous connective tissues and reducing crust thickness in comparison with Kollakhit coating. Kollakhit-Bol provided targeted stimulation of reparative processes in the treatment of grade IIIb burns by creating favorable conditions for grafting full thickness skin transplant or dermal-epidermal skin equivalent. In the topical treatment of thermal burn, Kollakhit-Bol application shortened the phases of alteration and exudation and accelerated transition to the productive phase of the infl ammatory process with phagocytosis and neoangiogenesis activation.

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Authors and Affiliations

  1. Prof. P. G. Podzolkov Department of Pathological Anatomy, V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia

    A. K. Kirichenko

  2. Department of Surgery and Topographic Anatomy, V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia

    I. N. Bolshakov & A. A. Vlasov

Authors
  1. A. K. Kirichenko
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  2. I. N. Bolshakov
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  3. A. E. Ali-Rizal
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  4. A. A. Vlasov
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Corresponding author

Correspondence to A. K. Kirichenko.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 154, No. 11, pp. 652-656, November, 2012

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Kirichenko, A.K., Bolshakov, I.N., Ali-Rizal, A.E. et al. Morphological Study of Burn Wound Healing with the Use of Collagen-Chitosan Wound Dressing. Bull Exp Biol Med 154, 692–696 (2013). https://doi.org/10.1007/s10517-013-2031-6

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  • DOI: https://doi.org/10.1007/s10517-013-2031-6

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