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Effect of Dopamine on Ehrlich Ascites Carcinoma Cells

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Morphological studies showed that daily intraperitoneal injections of dopamine in doses of 10–2 and 10–1 M down-regulates the general number of cells in the Ehrlich ascites carcinoma in 10 and 30 times and decreases their diameter by 27% and 59%, respectively (as compared to the control animals received physiological saline). According to ultrastructural data these injections were followed by the abnormal changes in microvilluses, forming the specifi c moiré fringes in cytosol, thickening of cortical layer, and a signifi cant increase in fi lament reticulum density (actin fi bers) in tumor cells of treatment group specimens. We concluded that the oncocytotoxic effect of dopamine was related to the induced polymerization of cytosol actin.

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Authors and Affiliations

  1. Institute of Theoretical and Experimental Biophysics, Russian Academy of Science, Pushchino, Moscow Region, Russia

    D. A. Moshkov, S. P. Romanchenko, E. Yu. Parnyshkova, E. N. Bezgina, S. I. Zaichkina & L. L. Pavlik

Authors
  1. D. A. Moshkov
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  2. S. P. Romanchenko
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  3. E. Yu. Parnyshkova
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  4. E. N. Bezgina
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  5. S. I. Zaichkina
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  6. L. L. Pavlik
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Corresponding authors

Correspondence to D. A. Moshkov or E. Yu. Parnyshkova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 154, No. 11, pp. 646-651, November, 2012

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Moshkov, D.A., Romanchenko, S.P., Parnyshkova, E.Y. et al. Effect of Dopamine on Ehrlich Ascites Carcinoma Cells. Bull Exp Biol Med 154, 686–691 (2013). https://doi.org/10.1007/s10517-013-2030-7

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  • DOI: https://doi.org/10.1007/s10517-013-2030-7

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