Coexpression of two mRNA isoforms for insulin-like growth factor-1 (IGF-1A and IGF-1B) and expression of YB-1 mRNA were analyzed in the bone marrow aspirates from 19 patients with multiple myeloma. It was shown that mRNA isoforms for IGF-1A and IGF-1B were mainly expressed in samples with hyperexpression of YB-1 mRNA, and, on the contrary, practically were not expressed (except sporadic cases) in samples with low level of YB-1 mRNA expression. Coexpression of mRNA isoforms for IGF-1A and IGF-1B were observed in 80% patients with multiple myeloma.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 154, No. 11, pp. 611–615, November, 2012
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Shushanov, S.S., Mar’ina, L.G., Kravtsova, T.A. et al. Coexpression of Two mRNA Isoforms of Insulin-Like Growth Factor-1 Gene and mRNA of YB-1 Gene in Patients with Multiple Myeloma. Bull Exp Biol Med 154, 654–657 (2013). https://doi.org/10.1007/s10517-013-2023-6
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DOI: https://doi.org/10.1007/s10517-013-2023-6