We compared activity of peritoneal macrophages in rats during normal pregnancy and under the action of NO-synthase inhibitor L-NAME, of E. coli LPS, SOD, and α-tocopherol analogue trolox. In non-pregnant rats, E. coli LPS stimulated peritoneal macrophages, while L-NAME produced a dose-dependent effect. During pregnancy, E. coli LPS activated phagocytosis, while antioxidants trolox, SOD, and L-NAME produced an inhibitory effect.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 154, No. 11, pp. 532-534, November, 2012
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Ivanova, A.S., Popova, I.G. & Nazarov, S.B. Effect of Antioxidants and Nitric Oxide on Activity of Peritoneal Macrophages in Albino Rats during Normal Pregnancy. Bull Exp Biol Med 154, 581–583 (2013). https://doi.org/10.1007/s10517-013-2003-x
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DOI: https://doi.org/10.1007/s10517-013-2003-x