Using a TV device for studying microcirculation (×40), we studied the density of the whole microvascular network and arteriolar its compartment in the pia mater of the sensorimotor cortex in rats of different age (2–3, 12, and 24 months) after intracerebral transplantation of mesenchymal stem cells or nutrient medium (control). The density of the microvascular network in the pia mater remained practically unchanged until 1 year, but then decreased by 1.8 times with adding (up to 2 years). MSC transplantation 1.5-1.8-fold increased the density of the pial microvessels in animals of all age groups in comparison with intact and control rats; the density of the arteriolar compartment increased by 2.1-2.4 times. Intracerebral injection of MSC to 1-year-old animals prevented pathological decrease in the density of microvascular network during the next year of life.
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Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 4, pp. 205–209, November, 2012
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Sokolova, I.B., Sergeev, I.V., Anisimov, S.V. et al. Effect of Transplantation of Mesenchymal Stem Cells on the Density of Pial Microvascular Network in Rats of Different Age. Bull Exp Biol Med 154, 548–552 (2013). https://doi.org/10.1007/s10517-013-1997-4
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DOI: https://doi.org/10.1007/s10517-013-1997-4