Skip to main content
SpringerLink
Log in

Effect of AMPD1 Gene Polymorphism on Muscle Activity in Humans

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Physical activity phenotypes are highly poligenic. Skeletal muscle-specific AMP deaminase isoform, encoded by AMPD1 gene, is stimulated after short-term highly intense exercise and is an important regulator of muscular energy metabolism in exercise. Analysis of restriction fragment length polymorphisms detected much lesser frequency of AMPD1 allele T and genotype TT in athletes engaged in the high-speed and strength sports (N=305) in comparison with humans practicing no sports (N=499). Hence, AMPD1 gene polymorphism C34T can be considered as a marker of liability to the high-speed and strength muscular activity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. I. I. Ahmetov, A. G. Williams, D. V. Popov, et al., Hum. Genet., 126, No. 6, 751–761 (2009).

    Article  PubMed  CAS  Google Scholar 

  2. M. K. Bolla, L. Haddad, S. E. Humphries, et al., Clin. Chem., 41, No. 11, 1599–1604 (1995).

    PubMed  CAS  Google Scholar 

  3. M. S. Bray, J. M. Hagberg, L. Perusse, et al., Med. Sci. Sports Exerc., 41, No. 1, 35–73 (2009).

    Article  PubMed  Google Scholar 

  4. H. Fischer, M. Esbjörnsson, R. L. Sabina, et al., J. Appl. Physiol., 103, No. 1, 315–322 (2007).

    Article  PubMed  CAS  Google Scholar 

  5. G. Lippi, U. G. Longo, and N. Maffulli, Br. Med. Bull., 93, 27–47 (2010).

    Article  PubMed  Google Scholar 

  6. T. Morisaki, M. Gross, H. Morisaki, et al., Proc. Natl. Acad. Sci. USA, 89, No. 14, 6457–6461 (1992).

    Article  PubMed  CAS  Google Scholar 

  7. B. Norman, D. K. Mahnke-Ziselman, A. Vallis, and R. L. Sabina, J. Appl. Physiol., 85, No. 4, 1273–1278 (1998).

    PubMed  CAS  Google Scholar 

  8. B. Norman, R. L. Sabina, and E. Jansson, Ibid., 91, No. 1, 258–264 (2001).

    CAS  Google Scholar 

  9. J. Rico-Sanz, T. Rankinen, D. R. Joanisse, et al., Physiol. Genomics, 14, No. 2, 161–166 (2003).

    PubMed  CAS  Google Scholar 

  10. J. C. Rubio, M. A. Martin, F. Rabadan, et al., J. Appl. Physiol., 98, No. 6, 2108–2112 (2005).

    Article  PubMed  CAS  Google Scholar 

  11. A. G. Williams and J. P. Folland, J. Physiol., 586, No. 1, 113–121 (2008).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. St. Petersburg Institute of Physical Culture, St. Petersburg, Russia

    O. N. Fedotovskaya & I. I. Akhmetov

  2. Kazan State Medical University, Kazan, Russia

    A. A. Danilova & I. I. Akhmetov

Authors
  1. O. N. Fedotovskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. A. Danilova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. I. I. Akhmetov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to O. N. Fedotovskaya.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 154, No. 10, pp. 485–487, October, 2012

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fedotovskaya, O.N., Danilova, A.A. & Akhmetov, I.I. Effect of AMPD1 Gene Polymorphism on Muscle Activity in Humans. Bull Exp Biol Med 154, 489–491 (2013). https://doi.org/10.1007/s10517-013-1984-9

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-013-1984-9

Key Words

Search

Navigation