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Characteristics of Heme Oxygenase-1 Expression in Rat Hepatocytes during the Development of Nonalcoholic Steatohepatitis

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We studied heme oxygenase-1 expression in rat liver during the development of nonalcoholic steatohepatitis simulated by feeding high-fat ration for 30, 90, and 180 days. Increased number of hepatocytes synthesizing heme oxygenase-1 was demonstrated at all stages of pathology development. Herewith, the intensity of enzyme expression by individual cells was reduced on experimental day 180 during the development of liver fibrosis.

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References

  1. A. O. Bueverov, Vrach, No. 7, 33–37 (2006).

  2. V. I. Korzhov, A. V. Vidmachenko, and M. V. Korzhov, Zhurn. AMN Ukrainy, 16, No. 1, 23–37 (2010).

    CAS  Google Scholar 

  3. O. N. Korneyeva, O. M. Drapkina, Ch. S. Pavlov, et al., Gastroenterologiya, No. 2, 18–21 (2007).

  4. E. B. Menshchikova, V. Z. Lankin, N. K. Zenkov, et al., Oxidative stress. Prooxidants and antioxidants [in Russian], Moscow (2006).

  5. Yu. K. Karaman, T. P. Novgorodtseva, N. V. Bivalkevich, et al., RF Patent No. 2394281, A Way of Modeling Nonalcoholic Steatohepatitis in Rats [in Russian], Byull. No.19, 10.07.2010.

  6. D. S. Sarkisov and Yu. L. Perov, Microscopic Methods. Manual [in Russian], Moscow (1996).

  7. M. Yu. Smirnova, L. Kh. Dzhemlikhanova, I. N. Kostyuchek, et al., Arkhiv patol., No. 1, 51–55 (2010).

  8. N. Abraham and A.Kappas, Pharmacol. Rev., 60, No. 1, 79–127 (2008).

    Article  PubMed  CAS  Google Scholar 

  9. Fatty Liver Disease: NASH and Related Disorders / Eds. G. C. Farrell, et al., Oxford (2005).

  10. Heme Oxygenase: the Elegant Orchestration of Its Products in Medicine, Eds. L. Otterbein, et al., N.Y. (2005).

  11. H. Kojima, S. Sakurai, M. Uemura, et al., Alcohol. Clin. Exp. Res., 29, No. 12, Suppl., 259S–263S (2005).

    Article  PubMed  Google Scholar 

  12. L. Li, P. Grenard, J. Nhieu, et al., Gastroenterology, 125, No. 2, 460–469 (2003).

    Article  PubMed  CAS  Google Scholar 

  13. I. Petrache, L. Otterbein, J. Alam, et al., Am. J. Physiol. Lung. Cell Mol. Physiol., 278, No. 2, L312–L319 (2000).

    PubMed  CAS  Google Scholar 

  14. V. Vijayan, S. Mueller, E. Baumgart-Vogt, and S. Immenschuh, World J. Gastroenterol., 16, No. 25, 3112–3119 (2010).

    Article  PubMed  CAS  Google Scholar 

  15. F. Wang, Zh. Duan, and Y.Sun, World J. Gastroenterol., 15, No. 24, 3009–3014 (2009).

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Vladivostok Branch of Far-Eastern Research Center of Physiology and Pathology of Respiration, Siberian Division of the Russian Academy of Medical Sciences, Research Institute of Medical Climatology and Restoring Treatment, Vladivostok, Russia

    Yu. K. Karaman, N. V. Bivalkevich, T. P. Novgorodtseva & T. A. Gvozdenko

Authors
  1. Yu. K. Karaman
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  2. N. V. Bivalkevich
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  3. T. P. Novgorodtseva
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  4. T. A. Gvozdenko
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Corresponding author

Correspondence to N. V. Bivalkevich.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 154, No. 10, pp. 425–427

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Karaman, Y.K., Bivalkevich, N.V., Novgorodtseva, T.P. et al. Characteristics of Heme Oxygenase-1 Expression in Rat Hepatocytes during the Development of Nonalcoholic Steatohepatitis. Bull Exp Biol Med 154, 431–434 (2013). https://doi.org/10.1007/s10517-013-1969-8

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  • DOI: https://doi.org/10.1007/s10517-013-1969-8

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