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Effect of Antibodies to Glutamate on Caspase-3 Activity in Brain Structures of Rats with Experimental Alzheimer’s Disease

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Bulletin of Experimental Biology and Medicine Aims and scope

Experiments on rats have showed that neurodegenerative damage to the brain induced by injection of a neurotoxic β-amyloid protein fragment Aβ25-35 into the basal giant cell nuclei of Meynert activated caspase-3 in the prefrontal cortex and hippocampus on day 3 after injury. Intranasal administration of antibodies to glutamate in a dose of 300 μg/kg 1 h after damage reduced enzyme activity in these structures in a rat model of Alzheimer’s disease.

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Authors and Affiliations

  1. Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia

    V. V. Kolobov, I. A. Zakharova, V. G. Fomina, V. Yu. Gorbatov & T. V. Davydova

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  1. V. V. Kolobov
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  2. I. A. Zakharova
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  3. V. G. Fomina
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  4. V. Yu. Gorbatov
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  5. T. V. Davydova
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Corresponding author

Correspondence to V. V. Kolobov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 154, No. 10, pp. 417-420, October, 2012

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Kolobov, V.V., Zakharova, I.A., Fomina, V.G. et al. Effect of Antibodies to Glutamate on Caspase-3 Activity in Brain Structures of Rats with Experimental Alzheimer’s Disease. Bull Exp Biol Med 154, 425–427 (2013). https://doi.org/10.1007/s10517-013-1967-x

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  • DOI: https://doi.org/10.1007/s10517-013-1967-x

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