Skip to main content
SpringerLink
Log in

Expression of Renin–Angiotensin System Genes in Brain Structures of ISIAH Rats with Stress-Induced Arterial Hypertension

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

We studied the expression of genes encoding angiotensinogen (Agt), renin (Ren), angiotensinconverting enzyme (ACE), and type 1 angiotensin receptor (AT1A) in the hypothalamus and medulla oblongata of hypertensive ISIAH rats and normotensive WAG rats. The amount of Agt mRNA in the hypothalamus of young ISIAH rats was increased by 30% compared to WAG controls. In the medulla oblongata of young ISIAH rats, the levels of mRNA of Agt and AT1A receptor were enhanced by 60% and 24%, respectively, compared to WAG rats. In adult animals, the expression of the studied genes did not differ from the control. It is concluded that changes in gene expression of the renin—angiotensin system in brain structures of ISIAH rats may contribute to the development of hypertension.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. L. A. Fedoseeva, G. M. Dymshits, A. L. Markel, G. S. Jakobson, et al., Byull. Eksper. Biol., 147, No. 2, 134-138 (2009).

    Google Scholar 

  2. M. D. Shmerling, V. F. Maksimov, E. E. Filyushina, et al., Byull. SO RAMN, 30, No.4, 62-67 (2010).

    Google Scholar 

  3. S. Amstislavsky, P. Welker, J. H. Fruhauf, et al., Histochem. Cell Biol., 125, No. 6, 651-659 (2005).

    Article  PubMed  Google Scholar 

  4. L. A. Fedoseeva, Ryazanova M.A., Antonov E.V., et al., Biochemistry (Mosc.). Suppl. Series B: Biomed. Chem., 5, No. 1, 37-43 (2011).

    Article  Google Scholar 

  5. A. Hamaguchi, S. Kim, Y. Izumi, and H. Iwao, J. Am. Soc. Nephrol., 11, No. 1, 39-46 (2000).

    PubMed  CAS  Google Scholar 

  6. S. Kagiyama, T. Tsuchihashi, I. Abe, et al., Brain Res., 829, Nos. 1-2, 120-124 (1999).

    Article  PubMed  CAS  Google Scholar 

  7. C. Komatus, K. Shibata, T. Furukawa, et al., Life Sci., 58, No. 14, 1109-1121 (1996).

    Article  PubMed  CAS  Google Scholar 

  8. A. L. Markel, in: Genetic Hypertension, Ed. J. Sassard, 218, 405-407 (1992).

  9. A. L. Markel, O. E. Redina, M. A. Gilinsky, et al., J. Endocrinol., 195, No. 3, 439-450 (2007).

    Article  PubMed  CAS  Google Scholar 

  10. C. G. Park and F. H. Leenen, J. Korean. Med. Sci., 16, No. 5, 553-557 (2001).

    PubMed  CAS  Google Scholar 

  11. M. I. Phillips, D. Mohuczy-Dominiak, M. Coffey, et al., Hypertension, 29, No. 1, Pt. 2, 374-380 (1997).

  12. P. Ruiz, N. Basso, M. A. Cannata, and A. C. Taquini, Clin. Exp. Hypertens., 12, No. 1, 63-81 (1990).

    Article  CAS  Google Scholar 

  13. M. Schinke, O. Baltatu, M. Bohm, et al., Proc. Natl. Acad. Sci. USA, 96, No. 97, 3975-3980 (1999).

    Article  PubMed  CAS  Google Scholar 

  14. K. Shibata, C. Komatsu, Y. Misumi, and T. Furukawa, Brain Res. Mol. Brain Res., 19, Nos. 1-2, 115-120 (1993).

    Article  PubMed  CAS  Google Scholar 

  15. K. Tamura, S. Umemura, N. Nyui, et al., Hypertension, 27, No. 6, 1216-1223 (1996).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

    L. A. Fedoseeva, M. A. Ryazanova, G. M. Dymshits & A. L. Markel

  2. Novosibirsk State University, Novosibirsk, Russia

    L. O. Klimov, L. A. Fedoseeva, G. M. Dymshits & A. L. Markel

Authors
  1. L. O. Klimov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L. A. Fedoseeva
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. A. Ryazanova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G. M. Dymshits
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. L. Markel
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to L. O. Klimov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 154, No. 9, pp. 342-345, September, 2012

Rights and permissions

Reprints and permissions

About this article

Cite this article

Klimov, L.O., Fedoseeva, L.A., Ryazanova, M.A. et al. Expression of Renin–Angiotensin System Genes in Brain Structures of ISIAH Rats with Stress-Induced Arterial Hypertension. Bull Exp Biol Med 154, 357–360 (2013). https://doi.org/10.1007/s10517-013-1950-6

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-013-1950-6

Keywords

Search

Navigation