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The Role of ADRB2 in Myasthenia: Genetic and Immunological Factors

  • GENETICS
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Bulletin of Experimental Biology and Medicine Aims and scope

To examine the possibility of using ADRB2 adrenergic receptor agonists for correction of myasthenia-induced immunological and motor disturbances, a method of anti-ADRB2 antibody assay by ELISA was developed. The haplotype of ADRB2 gene was determined by MLPA-PCR in 34 myasthenia patients; blood sera from 40 patients were examined. The content of antibodies against ADRB2 receptors was elevated in 12 of 30 patients with generalized form of myasthenia. Arg-Arg in position 16 in ADRB2 receptors determines the developmental risk of side effects, while Gly-Gly in the same codon determines tolerance to β2-adrenoceptor agonists and is associated with more severe course of myasthenia and resistance to β2-adrenoceptor agonists treatment with ADRB2 agonists. The study demonstrated the possibility of using ADRB2 obtained gene engineering technique for quantitatively assay the autoantibodies.

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Authors and Affiliations

  1. Research Center of Neurology, Russian Academy of Medical Sciences, Moscow, Russia

    V. B. Lantsova & E. K. Sepp

  2. Bioengineering Center, Russian Academy of Sciences, Moscow, Russia

    A. S. Gerasimov

Authors
  1. V. B. Lantsova
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  2. A. S. Gerasimov
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  3. E. K. Sepp
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Corresponding author

Correspondence to V. B. Lantsova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 154, No. 9, pp. 336-338, September, 2012

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Lantsova, V.B., Gerasimov, A.S. & Sepp, E.K. The Role of ADRB2 in Myasthenia: Genetic and Immunological Factors. Bull Exp Biol Med 154, 351–353 (2013). https://doi.org/10.1007/s10517-013-1948-0

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  • DOI: https://doi.org/10.1007/s10517-013-1948-0

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