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Production of Early IL-1β Induced by Human Serum γ-Globulin Metal Complexes

  • IMMUNOLOGY AND MICROBIOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

Plasma γ-globulin fraction proteins, copper and zinc cations, and metal complexes formed by them with human serum γ-globulin induce the production of early (24-h incubation) IL-1β by human blood cells. The protein modifi ed by Zn cations 1.2 times more actively (p<0.01) induced early IL-1β than the control γ-globulin, while γ-globulin metal complex with copper was 1.4 times less active (p<0.1) than the control protein. The regularities of induction changed over the course of 48-h incubation: zinc cations chelated by γ-globulin fraction protein reduced, while copper cations stimulated the realization of the protein induction potential in the metal complex.

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Authors and Affiliations

  1. Laboratory of Cell-Cell Interactions, N. F. Gamaleya Institute of Epidemiology and Microbiology, Ministry of Health and Social Development of Russia, Moscow, Russia

    S. B. Cheknev, I. E. Efremova, L. S. Piskovskaya, E. N. Yushkovets & A. A. Babajanz

Authors
  1. S. B. Cheknev
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  2. I. E. Efremova
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  3. L. S. Piskovskaya
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  4. E. N. Yushkovets
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  5. A. A. Babajanz
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Correspondence to S. B. Cheknev.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 154, No. 9, pp. 326-329, September, 2012

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Cheknev, S.B., Efremova, I.E., Piskovskaya, L.S. et al. Production of Early IL-1β Induced by Human Serum γ-Globulin Metal Complexes. Bull Exp Biol Med 154, 343–345 (2013). https://doi.org/10.1007/s10517-013-1946-2

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  • DOI: https://doi.org/10.1007/s10517-013-1946-2

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