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Pentoxifylline Potentiates Antiepileptic Activity of Diazepam on the Model of Treatment-Resistant Focal Epilepsy

  • PHARMACOLOGY AND TOXICOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

Kindling-syndrome was modeled in male Wistar rats using repeated corazole administration (25-30 mg/kg intraperitoneally). The effects of pentoxifylline (25 and 100 mg/kg intraperitoneally) and diazepam (0.05 and 1 mg/kg intraperitoneally) were studied in 3 weeks after kindling development under conditions of acute observation on the model of penicillin-induced foci in cerebral cortex. An anticonvulsant effect of combined treatment with diazepam and pentoxifylline in the doses, ineffective if administered separately (0.05 and 25 mg/kg intraperitoneally), was demonstrated.

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Authors and Affiliations

  1. Odessa National Medical University, Odessa, Ukraine

    L. S. Godlevsky, E. V. Kobolev & V. A. Polyasnyi

  2. Peoples’ Friendship University of Russia, Moscow, Russia

    G. A. Drozdova & V. F. Mustyatsa

Authors
  1. L. S. Godlevsky
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  2. G. A. Drozdova
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  3. E. V. Kobolev
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  4. V. F. Mustyatsa
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  5. V. A. Polyasnyi
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Corresponding author

Correspondence to L. S. Godlevsky.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 154, No. 9, pp. 308-310, September, 2012

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Godlevsky, L.S., Drozdova, G.A., Kobolev, E.V. et al. Pentoxifylline Potentiates Antiepileptic Activity of Diazepam on the Model of Treatment-Resistant Focal Epilepsy. Bull Exp Biol Med 154, 326–328 (2013). https://doi.org/10.1007/s10517-013-1942-6

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  • DOI: https://doi.org/10.1007/s10517-013-1942-6

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