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Serotonin Metabolism in the Placenta in Exacerbation of Herpesvirus Infection during Pregnancy

  • VIROLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

Serotonin metabolism in the blood and placental homogenate was studied in pregnancy aggravated by exacerbation of herpesvirus infection. Blood serotonin content in pregnant patients increased with increasing herpesvirus antibody titers and reduction of monoamine oxidase activity. Urinary excretion of 5-hydroxyindoleacetic acid (5-HIAA) decreased. The decrease of monoamine oxidase activity in placental homogenate led to an increase of serotonin level, which was paralleled by destruction of mitochondria in the syncytiotrophoblast, suppression of BCL-2 protein activity, and increase of caspase-3 level.

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Authors and Affiliations

  1. Far-Eastern Research Center of Respiratory Physiology and Pathology, Siberian Division of the Russian Academy of Medical Sciences, Blagoveshchensk, Russia

    M. T. Lutsenko & I. A. Andrievskaya

Authors
  1. M. T. Lutsenko
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  2. I. A. Andrievskaya
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Correspondence to M. T. Lutsenko.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 154, No. 8, pp. 221–225, August, 2012

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Lutsenko, M.T., Andrievskaya, I.A. Serotonin Metabolism in the Placenta in Exacerbation of Herpesvirus Infection during Pregnancy. Bull Exp Biol Med 154, 255–259 (2012). https://doi.org/10.1007/s10517-012-1925-z

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  • DOI: https://doi.org/10.1007/s10517-012-1925-z

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