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Amphetamine and Methamphetamine Have a Direct and Differential Effect on BV2 Microglia Cells

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Bulletin of Experimental Biology and Medicine Aims and scope

A comparative analysis of the direct effects of amphetamine and methamphetamine exposure on BV2 microglia cells in the presence and absence of cellular debris was performed. A significant dose-dependent and treatment-dependent effect of amphetamine and methamphetamine on BV2 cells was demonstrated: methamphetamine, but not amphetamine, inhibited phagocytosis, and a differential regulation of cytokines was observed in response to amphetamine and methamphetamine.

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Authors and Affiliations

  1. Department of Biology, 82 College Circle, Dahlonega, GA, 30597, USA

    R. A. Shanks, J. R. Anderson & J. R. Taylor

  2. Department of Psychology, North Georgia College & State University, 82 College Circle, Dahlonega, GA, 30597, USA

    S. A. Lloyd

Authors
  1. R. A. Shanks
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  2. J. R. Anderson
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  3. J. R. Taylor
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  4. S. A. Lloyd
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Corresponding author

Correspondence to R. A. Shanks.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 154, No. 8, pp. 192-191, August, 2012

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Shanks, R.A., Anderson, J.R., Taylor, J.R. et al. Amphetamine and Methamphetamine Have a Direct and Differential Effect on BV2 Microglia Cells. Bull Exp Biol Med 154, 228–232 (2012). https://doi.org/10.1007/s10517-012-1919-x

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  • DOI: https://doi.org/10.1007/s10517-012-1919-x

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