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Effect of 3,5-Dicarbomethoxyphenylbiguanide on Free Radical Homeostasis in Rats with Experimental Myocarditis

Bulletin of Experimental Biology and Medicine volume 154, pages 192–195 (2012)Cite this article

Administration of 3,5-dicarbomethoxyphenylbiguanide to rats with experimental epinephrineinduced myocarditis was followed by a decrease in activity of marker enzymes for cardiomyocyte cytolysis in the blood serum. This agent also decreased the intensity of free radical processes and had a normalizing effect on aconitase activity in the heart and blood serum of rats with myocarditis.

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Affiliations

  1. Department of Medical Biochemistry and Microbiology, Voronezh State University, Voronezh, Russia

    E. S. Tanigina, A. V. Semenikhina, T. N. Popova, L. V. Matasova & E. D. Kryl’skiy

Authors
  1. E. S. Tanigina
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  2. A. V. Semenikhina
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  3. T. N. Popova
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  4. L. V. Matasova
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  5. E. D. Kryl’skiy
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Corresponding author

Correspondence to L. V. Matasova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 154, No. 8, pp. 154–157, August, 2012

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Tanigina, E.S., Semenikhina, A.V., Popova, T.N. et al. Effect of 3,5-Dicarbomethoxyphenylbiguanide on Free Radical Homeostasis in Rats with Experimental Myocarditis. Bull Exp Biol Med 154, 192–195 (2012). https://doi.org/10.1007/s10517-012-1909-z

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  • DOI: https://doi.org/10.1007/s10517-012-1909-z

Key Words

  • myocarditis
  • biguanides
  • free radical processes
  • antioxidants
  • rats