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Proliferative Response of Lymphocyte to Pokeweed Mitogen Depends on the Concentration of Endogenous Cortisol in the Early Post-Traumatic Period in Patients with Penetrating Eye Injury

  • MICROBIOLOGY AND IMMUNOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

The intensity of lymphocyte proliferation in response to pokeweed mitogen depends on cortisol level in the peripheral blood in the early post-traumatic period of penetrating eye injury. Lymphocyte proliferation in 72- and 96-h cultures from patients with high levels of endo genous hormone was suppressed. In 120-h cultures, the intensity of proliferation remains unchanged. Lymphocyte blast transformation was increased in 120-h cultures from patients with normal cortisol concentration and remained unchanged in case of low cortisol level.

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References

  1. L. T. Arkhipova, Sympathetic Ophthalmia [in Russian], Moscow (2006).

  2. N. L. Berkasova, T. V. Gavrilova, Yu. I. Shilov, et al., Byull. Eksp. Biol. Med., 145, No. 3, 313-315 (2008).

    Article  Google Scholar 

  3. I. A. Volchegorskii, I. I. Dogushin, O. L. Kolesnikov, and V. E. Tsyeilikman, Experimental Simulation and Laboratory Evaluation of Adaptive Reactions of the Body [in Russian], Chelyabinsk (2000).

  4. V. I. Kulinskii and I. A. Olkhovskii, Uspekhi Sovrem. Biol., 112, No. 5-6, 697-714 (1992).

    CAS  Google Scholar 

  5. O. S. Slepova, Vestn. Uralsk. Med. Akad. Nauki, No. 1, 24-30 (2005).

  6. V. A. Chereshnev, Yu. I. Shilov, M. V. Chereshneva, et al., Ros. Immunol. Zh., 4, No. 3, 225-236 (2010).

    Google Scholar 

  7. M. V. Chereshneva, Yu. I. Shilov, O. N. Badanina, et al., Immunocorrection in Eye Injury [in Russian], Ekaterinburg (2001).

  8. M. V. Chereshneva, Yu. I. Shilov, T. V. Gavrilova, et al., Vestn. Oftalmol., No. 2, 42-46 (2006).

  9. V. V. Chuprina, V. E. Denisov, Yu. I. Shilov, et al., Vestn. Uralsk. Med. Akad. Nauki, No. 3/1 (14), 273-275 (2006).

  10. Yu. I. Shilov, V. V. Chuprina, T. V. Gavrilova, et al., Vestn. Uralsk. Med. Akad. Nauki, No. 2/1 (24), 188-189 (2009).

  11. J. Bartova, Z. Kratka-Opatrna, J. Prochazkova, et al., Mediators Infl amm., 9, No. 2, 115-120 (2000).

    Article  CAS  Google Scholar 

  12. F. Lei, J. Zhang, J. Zhang, et al., Mol. Vis., 14, 327-333 (2008).

    PubMed  CAS  Google Scholar 

  13. J. Y. Niederkorn, Expert Rev. Clin. Immunol., 5, No. 2, 137-144 (2009).

    Article  PubMed  CAS  Google Scholar 

  14. H. M. Ogmundsdóttir, S. Sveinsdóttir, A. Sigfússon, et al., Clin. Exp. Immunol., 117, No. 2, 252-260 (1999).

    Article  PubMed  Google Scholar 

  15. J. Stein-Streilein and A. W. Taylor, J. Leukoc. Biol., 81, No. 3, 593-598 (2007).

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences, Perm, Russia

    V. A. Chereshnev, Ju. I. Shilov, T. V. Gavrilova, V. V. Usov & M. V. Chereshneva

  2. Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences, Ekaterinburg, Russia

    V. A. Chereshnev, Ju. I. Shilov, T. V. Gavrilova, V. V. Usov & M. V. Chereshneva

  3. E. A. Vagner Perm State Medical Academy, Perm, Russia

    V. A. Chereshnev, Ju. I. Shilov, T. V. Gavrilova, V. V. Usov & M. V. Chereshneva

Authors
  1. V. A. Chereshnev
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  2. Ju. I. Shilov
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  3. T. V. Gavrilova
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  4. V. V. Usov
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  5. M. V. Chereshneva
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Corresponding author

Correspondence to Ju. I. Shilov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 153, No. 5, pp. 680-683, May, 2012

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Chereshnev, V.A., Shilov, J.I., Gavrilova, T.V. et al. Proliferative Response of Lymphocyte to Pokeweed Mitogen Depends on the Concentration of Endogenous Cortisol in the Early Post-Traumatic Period in Patients with Penetrating Eye Injury. Bull Exp Biol Med 153, 722–725 (2012). https://doi.org/10.1007/s10517-012-1810-9

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  • DOI: https://doi.org/10.1007/s10517-012-1810-9

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