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Loperamide Effects on Anxiety Level and Feeding Behavior in Rats. Role of Vagal Afferentation

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Bulletin of Experimental Biology and Medicine Aims and scope

We investigated the role of vagal afferentation in the interaction of the peripheral and central parts of the endogenous opioid system, in the mechanisms of sensorial satiation and anxiety in rats. It has been established that vagotomized rats spent less time in open arm of the plus-maze in comparison with sham-operated animals. Peripheral administration of μ-opioid receptor agonist loperamide was shown to reduce anxiety level in sham-operated rats and had no effect on this parameter in vagotomized animals. Testing in a PhenoMaster module system showed that loperamide administration suppressed feeding behavior in sham-operated animals and partially suppressed it in vagotomized animals. Vagotomy virtually completely blocked the anxiolytic effect of loperamide and partially blocked the anorexigenic effect of the μ-opioid receptor agonist.

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Authors and Affiliations

  1. P.K.Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia

    S. K. Sudakov, V. G. Bashkatova, A. A. Kolpakov & N. N. Chernyaeva

Authors
  1. S. K. Sudakov
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  2. V. G. Bashkatova
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  3. A. A. Kolpakov
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  4. N. N. Chernyaeva
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Corresponding author

Correspondence to S. K. Sudakov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 153, No. 5, pp. 674-676, May, 2012

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Sudakov, S.K., Bashkatova, V.G., Kolpakov, A.A. et al. Loperamide Effects on Anxiety Level and Feeding Behavior in Rats. Role of Vagal Afferentation. Bull Exp Biol Med 153, 717–719 (2012). https://doi.org/10.1007/s10517-012-1808-3

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  • DOI: https://doi.org/10.1007/s10517-012-1808-3

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