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In Vitro Effects of Sporobacterin Probiotic on the Function of Donor Granulocyte-Macrophage Cells

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The effects of sporobacterin probiotic (Bakoren Company) on oxidative activity of donor granulocyte-macrophage cells (GMC) were studied in vitro by luminol-dependent chemiluminescent method, and the effects of the probiotic on the production of pro- and anti-infl ammatory cytokines were evaluated by ELISA. The probiotic dose-dependently stimulated spontaneous production of free radicals by GMC; combined treatment with immunomodulators likopid, polyoxydonium, and IFN-α2a produced a more potent effect. Sporobacterin stimulated the production of pro- and anti-infl ammatory cytokines in cell cultures. These data confi rmed the immunomodulatory effect of sporobacterin, an important component in the phagocytic system cells.

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Authors and Affiliations

  1. V. I. Shumakov Center of Transplantology and Artificial Organs, Moscow, Russia

    N. I. Gabrielyan, V. S. Suskova, S. I. Suskov & N. L. Vologodskaya

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  1. N. I. Gabrielyan
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  2. V. S. Suskova
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  3. S. I. Suskov
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  4. N. L. Vologodskaya
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Corresponding author

Correspondence to V. S. Suskova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 153, No. 5, pp. 653-655, May, 2012

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Gabrielyan, N.I., Suskova, V.S., Suskov, S.I. et al. In Vitro Effects of Sporobacterin Probiotic on the Function of Donor Granulocyte-Macrophage Cells. Bull Exp Biol Med 153, 697–699 (2012). https://doi.org/10.1007/s10517-012-1802-9

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  • DOI: https://doi.org/10.1007/s10517-012-1802-9

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