We studied the effects of neurotensin dipeptide analog Dilept (N-caproyl-L-prolyl-L-tyrosine methyl ester) on dopamine metabolism and synthesis in the nucleus accumbens of Wistar rats. Dilept increased the levels of dopamine and its metabolites (homovanillic acid and dioxyphenylalanine) and stimulated dopamine turnover in this structure. Dilept accelerated dopamine synthesis under conditions of pulsed activity blockade in dopaminergic neuron by injection of γ-butyrolactone combined with inhibition of aromatic acid decarboxylase with 3-hydroxybenzylhydrazine. The spectrum of pharmacological activities of Dilept towards the dopaminergic system of the nucleus accumbens was similar to that of atypical neuroleptics and neurotensin (endogenous antipsychotic).
Similar content being viewed by others
References
V. S. Kudrin, I. I. Miroshnichenko, and K. S. Raevskii, Neirokhimiya, 7, No. 1, 3-8 (1988).
I. I. Miroshnichenko, V. S. Kudrin, and K. S. Raevskii, Farmakol. Toksikol., 51, No. 2, 26-29 (1988).
S. B. Seredenin, T. A. Voronina, T. A. Gudasheva, et al., Substituted Prolyltyrosines with Psychotropic Activity, Patent of the Russian Federation No. 2091390 (1997).
E. B. Binder, B. Kinkead, M. J. Owens, and C. B. Nemeroff, Pharmacol. Rev., 53, No. 4, 453-486 (2001).
M. Boules, P. Fredrickson, and E. Richelson, Peptides, 27, No. 10, 2523-2533 (2006).
A. D. Drumheller, M. A. Gagné, S. St-Pierre, and F. B. Jolicoeur, Neuropeptides, 15, No. 3, 169-178 (1990).
T. A. Gudasheva, T. A. Voronina, R. U. Ostrovskaya, et al., J. Med. Chem., 41, No. 3, 284-290 (1998).
B. Kinkead and C. B. Nemeroff, Curr. Opin. Pharmacol., 2, No. 1, 99-103 (2002).
M. Najimi, J. J. Robert, J. Mallet, et al., Mol. Pharmacol., 62, No. 3, 647-653 (2002).
A. Reches, R. E. Burke, D. Jiang, et al., Peptides, 4, No. 1, 43-48 (1983).
T. M. Tzschentke, Prog. Neurobiol., 63, No. 3, 241-320 (2001).
J. R. Walters and R. H. Roth, Biochem. Pharmacol., 25, No. 6, 649-654 (1976).
D. R. Weinberger, Arch. Gen. Psychiatry, 44, No. 7, 660-669 (1987).
S. T. Yoshida, S. A. Baella, N. M. Stuebner, et al., Brain Res., No. 1073-1074, 269-275 (2006).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 153, No. 5, pp. 649-652, May, 2012
Rights and permissions
About this article
Cite this article
Shubenina, E.V., Kudrin, V.S., Klodt, P.M. et al. Effects of Neurotensin Dipeptide Analog Dilept on Dopamine Metabolism and Synthesis in the Nucleus Accumbens of Wistar Rats. Bull Exp Biol Med 153, 694–696 (2012). https://doi.org/10.1007/s10517-012-1801-x
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-012-1801-x