We studied the effect of IL-1β on antioxidant enzyme activity in emotiogenic structures of the brain (hypothalamus, sensorimotor cortex, and amygdala) in behaviorally passive and active rats with different sensitivity to stress. One-hour immobilization of animals with simultaneous electrocutaneous stimulation was used as a model of stress. An intraperitoneal injection of IL-1β (5 μg/kg) was followed by the decrease in glutathione reductase activity in the hypothalamus of rats. Behaviorally active animals of the IL-1β group were characterized by an increase in the activities of Cu/Zn superoxide dismutase and glutathione peroxidase in the sensorimotor cortex and amygdala, respectively. IL-1β administration was accompanied by activation of Cu/Zn superoxide dismutase and glutathione peroxidase in the amygdala of passive rats. Pretreatment with IL-1β abolished the poststress changes in enzyme activity in the hypothalamus and sensorimotor cortex of active and passive rats, respectively. These data illustrate the specifi c effects of IL-1β on antioxidant protection of CNS tissues in rats with various behavioral characteristics.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 153, No. 5, pp. 635-638, May, 2012
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Kalinichenko, L.S., Pertsov, S.S., Koplik, E.V. et al. Antioxidant Protection of the Brain in Rats during Acute Stress and Administration of Interleukin-1β. Bull Exp Biol Med 153, 680–683 (2012). https://doi.org/10.1007/s10517-012-1798-1
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DOI: https://doi.org/10.1007/s10517-012-1798-1