We studied the relationships between the blood serum levels of human leukemia differentiation factor HLDF, idiotypic and anti-idiotypic antibodies to HLDF, and clinical indicators of cardiovascular function in apparently healthy individuals and patients with essential hypertension and cerebral hypertensive crisis. Markedly reduced HLDF levels and anti-HLDF antibody titers were found in the blood of the examined patients. Correlations between HLDF levels, duration of hypertension, and systolic and diastolic BP were revealed. These findings suggest that the studied molecular factors are involved in the mechanisms of BP regulation under normal conditions and during hypertension development. The protein HLDF and anti-HLDF antibodies can be considered as biomarkers for early diagnosis of hypertension and its cerebral complications.
Similar content being viewed by others
References
I. N. Bokarev, Klin. Med., No. 8, 84–86 (2005).
E. I. Elistratova, M. A. Gruden, T. V. Davydova, and V. V. Sherstnev, Patol. Fiziol. i Eksper. Ter., No 3, 25–28 (2011).
A. B. Poletaev, Immunophysiology and Immunopathology [in Russian], Мoscow (2008).
D. I. Rzhevskii, S. M. Dranitsina, and L. K. Baidakova, Byull. Eksp. Biol. Med., 141, No. 6, 652–655 (2006).
G. M. Sinkova, Sibirskii Med. Zh., No. 8, 5–10 (2007).
V. I. Skvortsova, V. V. Sherstnev, N. A. Konstantinov, et al., Zh. Nevrol. Psikhiatr., 105, No. 8, 36–40 (2005).
V. V. Sherstnev, M. A. Gruden, V. I. Skvortsova, and V. A. Tabolin, Vestn. Ros. Acad. Med. Nauk, No. 6, 48–52 (2002).
V. V. Sherstnev, V. I. Skvortsova, M. A. Gruden, et al., Insult, No. 12, 53–59 (2004).
E. A. Shirokov and V. B. Simonenko, Klin. Med., No. 8, 4–7 (2001).
K. M. Busl and D. M. Greer, NeuroRehabilitation, 26, No. 1, 5–13 (2010).
A. J. Farrall and J. M. Wardlaw, Neurobiol. Aging, 30, No. 3, 337–352 (2009).
P. M. Kearney, M. Whelton, K. Reynolds, et al., Lancet, 365, 217–223 (2005).
R. D. Sewell, M. A. Gruden, D. M. Pache, et al., J. Psychopharmacol., 19, No. 6, 602–608 (2005).
E. Taoufi k and L. Probert, Curr. Pharm. Des., 14, No. 33, 3565–3573 (2008).
J. F. Vilela-Martin, R. O. Vaz-de-Melo, C. H. Kuniyoshi, et al., Hypertens Res., 34, No. 3, 367–371 (2011).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 153, No. 5, pp. 618-620, May, 2012
Rights and permissions
About this article
Cite this article
Elistratova, E.I., Gruden, M.A. & Sherstnev, V.V. Involvement of HLDF Protein and Anti-HLDF Antibodies in the Mechanisms of Blood Pressure Regulation in Healthy Individuals and Patients with Stable Hypertension and Hypertensive Crisis. Bull Exp Biol Med 153, 664–666 (2012). https://doi.org/10.1007/s10517-012-1793-6
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-012-1793-6