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Nociceptive Sensitivity and Lymphocytic Index of Peripheral Blood in Rats with Different Behavioral Activity in Model of Infl ammatory Pain Provoked by Injection of Freund’s Complete Adjuvant and Bovine Serum Albumin

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Nociceptive thresholds decreased in rats at the early stage of infl ammatory reaction induced by subcutaneous injection of BSA and complete Freund’s adjuvant. At the later stage of this reaction, there was a trend of restoring nociceptive parameters in behaviorally passive rats in contrast to active animals, which demonstrated further decrease in the nociceptive thresholds. During the late infl ammatory period, the lymphocytic index (by Shaganin) changed unidirectionally in the rats with different behavioral parameters. Probably, the changes in nociceptive thresholds were not triggered by the shift in lymphocyte/segmented neutrophil ratio, but resulted from production of yet not established biologically active agents with proalgesic and analgesic nature.

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Authors and Affiliations

  1. P. K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia

    E. V. Nikenina, A. Yu. Abramova & A. Yu. Kozlov

  2. I. M. Sechenov First Moscow State Medical University, Moscow, Russia

    E. V. Nikenina

Authors
  1. E. V. Nikenina
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  2. A. Yu. Abramova
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  3. A. Yu. Kozlov
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Correspondence to E. V. Nikenina.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 153, No. 5, pp. 582-584, May, 2012

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Nikenina, E.V., Abramova, A.Y. & Kozlov, A.Y. Nociceptive Sensitivity and Lymphocytic Index of Peripheral Blood in Rats with Different Behavioral Activity in Model of Infl ammatory Pain Provoked by Injection of Freund’s Complete Adjuvant and Bovine Serum Albumin. Bull Exp Biol Med 153, 631–633 (2012). https://doi.org/10.1007/s10517-012-1784-7

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  • DOI: https://doi.org/10.1007/s10517-012-1784-7

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