We studied central effects of delta-sleep-inducing peptide in the mechanisms of positive emotional state formation in rats. In Wistar rats preliminary tested in an open field, the reactions of 57 neurons of the dorsal hippocampus were analyzed during lateral hypothalamus stimulation and microionophoretic application of delta-sleep-inducing peptide. It was found that the number of neurons not responding to stimulation in the lateral hypothalamus surpassed the number of sensitive neurons (63 and 37%, respectively). Hippocampal neurons in active animals were less sensitive to stimulation of the lateral hypothalamus than in passive rats (33 vs. 42%) After application of delta-sleep-inducing peptide, only 28% neurons responded to stimulation. Thus, delta-sleep-inducing peptide reduced the sensitivity of hippocampal neurons to stimulation of the lateral hypothalamus.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
A. A. Grigor’ev, T. A. Ivanova, I. A. Kustova, et al., Byull. Eksp. Biol. Med., 142, No. 8, 186–188 (2006).
N. N. Danilova and A. L. Krylova, Physiology of Higher Nervous Activity [in Russian], Rostov-on-Don (2005).
E. V. Koplik, R. M. Salieva, and A. M. Gorbunova, Zh. Vyssh. Nervn. Deyat., 45, No. 4, 775–781 (1995).
L. F. Panchenko, N. V. Firstova, N. V. Mityushina, et al., Neirokhimiya, 17, No. 2, 83–92 (2000).
I. A. Prudchenko and I. I. Mikhaleva, Uspekhi Sovr. Biol., 114, No. 6, 728 (1994).
K. V. Sudakov, R. M. Salieva, K. Yanovskii, et al., Zh. Vyssh. Nervn. Deyat., 41, No. 3, 558–563 (1991).
P. E. Umryukhin, E. V. Koplik, I. A. Grivennikov, et al., Zh. Vyssh. Nervn. Deyat., 51, No. 2, 220–227 (2001).
E. A. Yumatov, Vestn. Ross. Akad. Med. Nauk., No. 11, 9–16 (1995).
E. A. Yumatov, Systemic Psychophysiology of Subjective State of a Human [in Russian], Moscow (2011).
M. Herrera-Marschits, Z. B. You, M. Goiny, et al., J. Neurochem., 66, No. 4, 1726–1735 (1996).
G. Paxinos and C. Watson, The Rat Brain in Stereotaxic Coordinates. 4th ed. New York (1998).
K. V. Sudakov, P. E. Umryukhin, E. V. Koplik, et al., Stress, 4, No. 2, 143–153 (2001).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 153, No. 5, pp. 561-564, May, 2012
Rights and permissions
About this article
Cite this article
Grigorchuk, O.S., Umriukhin, P.E. Neuronal Activity in the Dorsal Hippocampus after Lateral Hypothalamus Stimulation: Effects of Delta-Sleep-Inducing Peptide. Bull Exp Biol Med 153, 614–616 (2012). https://doi.org/10.1007/s10517-012-1779-4
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-012-1779-4