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Effect of Recombinant Erythropoietin on Functional Activity of Cultured Human Cells

  • Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

We studied the effect of recombinant human erythropoietin on functional activity of skin cells in vitro. It was found that erythropoietin stimulated proliferation of mesenchymal and epithelial cells and effectively protected epidermal HaCaT cells from apoptosis. Insignificant effect of erythropoietin on contraction of collagen gel by mesenchymal cells was revealed. These findings suggest that erythropoietin can be a promising component of wound-healing preparations.

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Authors and Affiliations

  1. N. K. Kol’tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia

    E. A. Emel’yanova, A. V. Kosykh, Yu. V. Sukhanov, E. A. Vorotelyak & A. V. Vasil’ev

Authors
  1. E. A. Emel’yanova
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  2. A. V. Kosykh
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  3. Yu. V. Sukhanov
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  4. E. A. Vorotelyak
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  5. A. V. Vasil’ev
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Corresponding author

Correspondence to E. A. Vorotelyak.

Additional information

Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 2, pp. 83-87, April, 2012

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Emel’yanova, E.A., Kosykh, A.V., Sukhanov, Y.V. et al. Effect of Recombinant Erythropoietin on Functional Activity of Cultured Human Cells. Bull Exp Biol Med 153, 554–558 (2012). https://doi.org/10.1007/s10517-012-1765-x

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  • DOI: https://doi.org/10.1007/s10517-012-1765-x

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