We compared the effect of NF-κB inhibitor aurothiomalate and voltaren on local inflammation in different types of immune response. Both substances reduced edema caused by sheep erythrocytes (Th1-type immune response) and local immediate-type hypersensitivity response induced with ovalbumin (Th2-dependent response). The anti-inflammatory effects of aurothiomalate were similar to those of voltaren during Th1-type immune response.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 153, No. 4, pp. 460-463, April, 2012
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Ligacheva, A.A., Ivanova, A.N., Belsky, Y.P. et al. Effect of NF-κB Inhibitor Aurothiomalate on Local Inflammation in Experimental Th1- and Th2-Type Immune Response. Bull Exp Biol Med 153, 472–474 (2012). https://doi.org/10.1007/s10517-012-1743-3
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DOI: https://doi.org/10.1007/s10517-012-1743-3