The study examined the antinociceptive potency of dipeptide compound GB-115 (amide N-6-phenylhexanoyl-glycyl-L-tryptophan) during thermal and chemical noxious stimulation of mice. Peroral administration of GB-115 (0.1-20 mg/kg) decreased the incidence of abdominal contractions induced with intraperitoneal acetic acid (0.75%). This effect was comparable to that of sodium diclofenac (20 mg/kg); it was only partially antagonized with naloxone indicating the presence of significant non-opioid component in analgesic effect of GB-115. Ability of this dipeptide to moderate the nociceptive response in tail flick test under a non-selective blockade of the opioid receptors with naloxone and the absence of similar analgesic potency assessed in the hot plate test attest to predominant effect of GB-115 on spinal opioid receptors.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 153, No. 4, pp. 455-459, April, 2012
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Kolik, L.G., Zhukov, V.N., Gudasheva, T.A. et al. Experimental Study of Antinociceptive Potency of Dipeptide GB-115 during Chemical and Thermal Stimulation. Bull Exp Biol Med 153, 468–471 (2012). https://doi.org/10.1007/s10517-012-1742-4
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DOI: https://doi.org/10.1007/s10517-012-1742-4