Accumulation of oxidized proteins (evaluated by the levels of carbonyl and SH groups) in tissues of 2-24-month-old rats (spleen > myocardium > testicles > liver > skeletal muscles) has been demonstrated. Exogenous delta sleep-inducing peptide injected subcutaneously to rats of different age in a dose of 100 μg/kg by monthly 5-day courses protected proteins of the studied tissues from oxidation; its effect was tissue-specific. Delta sleep-inducing peptide exhibited a hypoglycemic effect: it prevented nonenzymatic glycosylation of hemoglobin and reduced the level of defective protein molecules during aging.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
V. N. Anisimov, Molecular and Physiological Mechanisms of Aging [in Russian], St. Petersburg (2008).
T. I. Bondarenko, N. A. Zhigalova, E. A. Maiboroda, and I. I. Mikhaleva, Vopr. Biol. Med. Farm. Khim., No. 1, 38–43 (2010).
E. E. Dubinina, S. O. Burmistrov, D. A. Khodov, and G. E. Borotov, Vopr. Med. Khim., 41, No. 1, 24–26 (1995).
V. I. Lushchak, Biokhimiya, 72, No. 8, 995–1017 (2007).
I. I. Mikhaleva and B. O. Voitenkov, Nov. Lek. Prep., No. 3, 6–20 (2007).
A. A. Moskalev, Uspekhi Gerontol., 23, No. 1, 9–20 (2010).
L. E. Muravleva, V. B. Molotov-Luganskii, and D. A. Klyuev, Fundamental’n. Issled., No. 1, 74–77 (2010).
N. V. Pushkina and A. I. Lukash, Izv. SKNTsVSh., Natural Sciences, No. 2, 95–97 (1976).
G. A. Ryzhak and S. S. Konovalov, Geroprotectors and Prevention of Age-Associated Diseases [in Russian], St. Petersburg (2004).
E. V. Tereshina, Manual of Gerontology [in Russian], Moscow (2005).
V. Kh. Khavinson and V. N. Anisimov, Uspekhi Gerontol., 22, No. 1, 11–23 (2009).
F. S. Facchini, N. W. Hua, C. M. Reaven, and R. A. Stoohs, Free Radic. Biol. Med., 29, No. 12, 1302–1306 (2000).
M. V. Graf, H. P. Lorez, D. Gillessen, et al., Experientia, 37, No. 6, 625–627 (1981).
I. G. Popovich, B. O. Voitenkov, and V. N. Anisimov, Mech. Ageing Dev., 124, No. 6, 721–731 (2003).
P. W. Riddles, R. L. Plakeley, and B. Zermer, Anal. Biochem., 94, No. 2, 75–81 (1979).
G. R. Schacterle and R. L. Pollack, Anal. Biochem., 51, No. 2, 654–655 (1973).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 153, No. 3, pp. 350-354, March, 2012
Rights and permissions
About this article
Cite this article
Bondarenko, T.I., Sorokina, I.A., Mayboroda, E.A. et al. Effect of Delta Sleep-Inducing Peptide on Oxidative Modification of Proteins in Rat Tissues and Blood during Physiological Aging. Bull Exp Biol Med 153, 371–374 (2012). https://doi.org/10.1007/s10517-012-1719-3
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-012-1719-3