Pronounced antihypoxic and antioxidant effects of preventive injection of succinic acid, aminothiol antihypoxants gutimine and amtizol, and succinate-containing aminothiol antihypoxants gutimine succinate and amtizol succinate to Wistar rats with acute hypoxic hypoxia have been demonstrated. Exogenous succinic acid was inferior to aminothiol compounds by antihypoxic effect, but superior to them by its effect on the level of LPO products. Succinate in the aminothiol molecule modulated the intensity of their antihypoxic and antioxidant effects. It did not modulate the antihypoxic activity of amtizol, but reduced the antihypoxic effect of gutimine, presumably because of the physicochemical characteristics of aminothiols. Comparison of the intensities of antihypoxic and antioxidant effects of the studied drugs showed no direct relationship between these effects.
This is a preview of subscription content,to check access.
Access this article
Similar content being viewed by others
I. V. Zarubina and P. D. Shabanov, Molecular Pharmacology of Antihypoxants [in Russian], St. Petersburg (2004).
M. V. Lukk, I. V. Zarubina, and P. D. Shabanov, Eksp. Klin. Farmakol., 72, No. 4, 36–42 (2009).
L. D. Luk’yanova, Vestn. Rossiisk. Akad. Med. Nauk, No. 9, 3–12 (2000).
V. V. Marysheva, Obzor Klin. Farmakol. Lek. Ter., 5, No. 1, 17–26 (2007).
V. E. Novikov and S. O. Losenkova, Ibid., 3, No. 1, 2–14 (2004).
A. B. Tomchin, Khim. Farm. Zh., 32, No. 10, 38–44 (1998).
P. D. Shabanov, I. V. Zarubina, V. E. Novikov, and V. N. Tsygan, Metabolic Correctors of Hypoxia [in Russian], St. Petersburg (2010).
P. R. Correa, E. A. Kruglov, M. Thompson, et al., J. Hepatology, 47, No. 2, 262–269 (2007).
W. He, F. J. Miao, D. C. Lin, et al., Nature, 429, 188–193 (2004).
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 153, No. 3, pp. 313-317, March, 2012
About this article
Cite this article
Zarubina, I.V., Lukk, M.V. & Shabanov, P.D. Antihypoxic and Antioxidant Effects of Exogenous Succinic Acid and Aminothiol Succinate-Containing Antihypoxants. Bull Exp Biol Med 153, 336–339 (2012). https://doi.org/10.1007/s10517-012-1709-5