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Peptides Tissue-Specifically Stimulate Cell Differentiation during Their Aging

  • Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
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Bulletin of Experimental Biology and Medicine Aims and scope

We verified expression of CXCL12 and Hoxa3 transcription factors of differentiation in cultures of human embryonic pancreatic and bronchial cells and CXCL12 and WEGC1 factors in a culture of human prostatic fibroblasts. Reduced expression of these differentiation markers was detected in late-passage (aging) cultures. The expression of differentiation factors CXCL12, Hoxa3, and WEGC1 was tissue-specifically stimulated by short peptides: pancragen (Lys-Glu-Asp-Trp) in pancreatic cells, bronchogen (Ala-Glu-Asp-Leu) in bronchial epithelial cells, and vesugen (Lys-Glu-Asp) in fibroblasts. The inducing effect of peptides on the expression of differentiation factors was more pronounced in aged cultures, which can serve as a mechanism of their geroprotective effect.

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Authors and Affiliations

  1. I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia

    V. Kh. Khavinson

  2. St. Petersburg Institute of Bioregulation and Gerontology, Northwestern Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia

    V. Kh. Khavinson, N. S. Linkova, V. O. Polyakova, O. V. Kheifets, S. I. Tarnovskaya & I. M. Kvetnoy

Authors
  1. V. Kh. Khavinson
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  2. N. S. Linkova
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  3. V. O. Polyakova
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  4. O. V. Kheifets
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  5. S. I. Tarnovskaya
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  6. I. M. Kvetnoy
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Corresponding author

Correspondence to N. S. Linkova.

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Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 1, pp. 34-37, January, 2012

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Khavinson, V.K., Linkova, N.S., Polyakova, V.O. et al. Peptides Tissue-Specifically Stimulate Cell Differentiation during Their Aging. Bull Exp Biol Med 153, 148–151 (2012). https://doi.org/10.1007/s10517-012-1664-1

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  • DOI: https://doi.org/10.1007/s10517-012-1664-1

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