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Hepatoprotective Effects of Immobilized Granulocyte Colony-Stimulating Factor and Hyaluronidase Preparation and Their Mechanisms

  • Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

High hepatoprotective activity of granulocytic CSF and hyaluronidase immobilized using electron-beam immobilization technology was demonstrated on the model of CCl4-induced hepatitis: the preparations produced anticholestatic, anti-inflammatory, and antisclerotic effects. These effects developed against the background of stimulation of bone marrow multipotent precursor cells and their mobilization into circulation accompanied by an increase in the content of parenchymatous progenitor cells in the liver. The most pronounced positive effect was observed in combined treatment with the test preparations.

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Authors and Affiliations

  1. Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia

    A. M. Dygai, V. V. Zhdanov, G. N. Zyuzkov, L. A. Stavrova, L. A. Miroshnichenko, E. V. Udut, T. Yu. Khrichkova, E. V. Simanina, R. V. Gurto, A. V. Chaikovskiy, T. S. Markova, T. I. Fomina, L. A. Ermolaeva, T. V. Vetoshkina & T. Yu. Dubskaya

  2. Scientific Future Management Company, Novosibirsk, Russia

    A. V. Artamonov, A. A. Bekarev, P. G. Madonov & D. N. Kinsht

Authors
  1. A. M. Dygai
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  2. V. V. Zhdanov
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  3. G. N. Zyuzkov
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  4. L. A. Stavrova
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  5. L. A. Miroshnichenko
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  6. E. V. Udut
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  7. T. Yu. Khrichkova
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  8. E. V. Simanina
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  9. A. V. Artamonov
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  10. A. A. Bekarev
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  11. P. G. Madonov
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  12. D. N. Kinsht
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  13. R. V. Gurto
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  14. A. V. Chaikovskiy
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  15. T. S. Markova
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  16. T. I. Fomina
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  17. L. A. Ermolaeva
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  18. T. V. Vetoshkina
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  19. T. Yu. Dubskaya
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Corresponding author

Correspondence to A. M. Dygai.

Additional information

Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 1, pp. 14-18, January, 2012

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Dygai, A.M., Zhdanov, V.V., Zyuzkov, G.N. et al. Hepatoprotective Effects of Immobilized Granulocyte Colony-Stimulating Factor and Hyaluronidase Preparation and Their Mechanisms. Bull Exp Biol Med 153, 129–133 (2012). https://doi.org/10.1007/s10517-012-1660-5

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  • DOI: https://doi.org/10.1007/s10517-012-1660-5

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